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- Table of Contents
ACVRL1 Antibodies
AND ACVRL1 ELISA kits, ACVRL1 Proteins
Many biological assays use antibodies to detect ACVRL1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with ACVRL1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop ACVRL1 antibodies...
Designing a Western blot for ACVRL1? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the ACVRL1 Western Blot GuideDesigning an IHC experiment for ACVRL1? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.
Open the ACVRL1 IHC GuideACVRL1 Infographic by Boster Bio
All ACVRL1 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
ELISA, Flow Cytometry, IHC, WB
$370
Cat # A01468-2
100 μg/vial
Cat # A01468-2
100 μg/vial
Human
ELISA
$499
Cat # EK1518
96 wells/kit, with removable strips.
Cat # EK1518
96 wells/kit, with removable strips.
Mouse
ELISA
$499
Cat # EK1519
96 wells/kit, with removable strips.
Cat # EK1519
96 wells/kit, with removable strips.
Human
ELISA, Flow Cytometry, Functional Assay, Kinetics
$486
Cat # M01468-2
100 μg
Cat # M01468-2
100 μg
Human, Mouse, Rat
ELISA
$480
Cat # EKC1717
1 kit, containing one 96-well plate and all necessary reagents
Cat # EKC1717
1 kit, containing one 96-well plate and all necessary reagents
ACVRL1 Overview
Facts about Serine/threonine-protein kinase receptor R3.
Serine/threonine-protein kinase receptor R3 (ACVRL1)
Type I receptor for TGF-beta family ligands BMP9/GDF2 and BMP10 and important regulator of normal blood vessel growth. On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases.
Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. May bind activin also.
Gene Information
| Human | |
|---|---|
| Gene Name: | ACVRL1 |
| Uniprot: | P37023 |
| Entrez: | 94 |
Family
| Belongs to: |
|---|
| protein kinase superfamily |
Alternative Names
activin A receptor type II-like 1; activin A receptor, type II-like kinase 1; Activin receptor-like kinase 1; ACVRL1; ACVRLK1ORW2; ALK1; ALK-1; ALK1TGF-B superfamily receptor type I; EC 2.7.11; HHT; HHT2EC 2.7.11.30; serine/threonine-protein kinase receptor R3; SKR3; TSR-I
Molecular Weight
Mass (kDA):
56.124 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 12q13.13 |
| Sequence: | 12; NC_000012.12 (51906913..51923361) |
Subcellular Localizations
Cell membrane; Single-pass type I membrane protein.
Diseases
- Hereditary Hemorrhagic Telangiectasia
- Telangiectasis
- Arteriovenous Malformation
- Tumor Angiogenesis
- Epistaxis
- Neoplasms
- Hypertensive Disease
- Lymphoma
- Hemorrhage
- Vascular Diseases
- Pulmonary Hypertension
- Dysplasia
- Diffuse Large B-cell Lymphoma
Interacting Proteins
- LRG1
Pathways
- Angiogenesis
- Pathogenesis
- Cell Proliferation
- Cell Migration
- Endothelial Cell Proliferation
- Endothelial Cell Migration
- Tube Formation
- Localization
- Vasculogenesis
- Cell Adhesion
- Cell Differentiation
- Sprouting Angiogenesis
- Cell Death
PTMs
- Phosphorylation
- Dephosphorylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/ACVRL1
bosterbio.com/bosterbio-gene-info-cards/ACVRL1
References
PMID: 8397373 by ten Dijke P., et al. Activin receptor-like kinases: a novel subclass of cell-surface receptors with predicted serine/threonine kinase activity.
PMID: 8242742 by Attisano L., et al. Identification of human activin and TGF beta type I receptors that form heteromeric kinase complexes with type II receptors.