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- Table of Contents
Facts about Serine/threonine-protein kinase receptor R3.
Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. May bind activin also.
Human | |
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Gene Name: | ACVRL1 |
Uniprot: | P37023 |
Entrez: | 94 |
Belongs to: |
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protein kinase superfamily |
activin A receptor type II-like 1; activin A receptor, type II-like kinase 1; Activin receptor-like kinase 1; ACVRL1; ACVRLK1ORW2; ALK1; ALK-1; ALK1TGF-B superfamily receptor type I; EC 2.7.11; HHT; HHT2EC 2.7.11.30; serine/threonine-protein kinase receptor R3; SKR3; TSR-I
Mass (kDA):
56.124 kDA
Human | |
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Location: | 12q13.13 |
Sequence: | 12; NC_000012.12 (51906913..51923361) |
Cell membrane; Single-pass type I membrane protein.
As a biologist, you are most likely interested in the Boster Bio Anti-ALK-1/ACVRL1 Marker. You may have wondered if this antibody would work in different settings, or if it is suitable for your research. Boster Bio validates all of its antibodies for WB, ICC, and Immunofluorescence. Continue reading to learn more.
The Boster Bio Anti-ALK-1/ACVRL1 marker has been validated using ELISA, Flow Cymetry, and IHC-P. It reacts with Rat, Mouse, and Human. Its primary ingredient is Trehalose. It is ideal for researchers and can be used in a variety applications. Read on to find out more about this marker.
Before applying your antibody, ensure that you have received confirmation. Boster Bio analyzes all antibodies found in samples that were previously identified as positive or neutral by the manufacturer. WB is ideal for initial validation since monoclonal antibodies do not effective against denatured proteins. You can employ flow cytometry or IHC to ensure that your antibody is targeted. Use WB to identify proteins that are not targeted. Be sure to include negative controls. Additionally, Flow cytometry can assist in determining if the antibody generated by Boster Bio is specific for the protein targeted by. Negative control for IHC experiments is also important because they can determine whether there is a secondary antibody
Secondary antibodies On the other hand they are antibodies that result from immunizations of a host animal with an antibody of another species. In this instance, the primary antibody is a rabbit polyclonal antibodies and the secondary antibody is from a different species. The antibodies that result have distinct specificities, based on the characteristics of the immunized antibody.
Boster Bio has a large library of primary antibodies that can be used in many research applications. Their products have been validated with immunofluorescence, Western blotting, and ELISA. They also validate their products in the context of known positive or negative samples. Here is a brief description about the various types of antibodies Boster provides. We hope you enjoy the benefits of using Boster antibodies!
Boster Bio's Anti-AKT AKT1 antibody, catalog number A00024-1, has been validated by multiple platforms, including ELISA, Flow Cytometry, and immunohistochemistry. The product reacts to Human AKT1 or Human AKT2. The antibody is made in rabbits through repeated immunization with Recombinant Human AKT1 and AKT2 proteins.
PMID: 8397373 by ten Dijke P., et al. Activin receptor-like kinases: a novel subclass of cell-surface receptors with predicted serine/threonine kinase activity.
PMID: 8242742 by Attisano L., et al. Identification of human activin and TGF beta type I receptors that form heteromeric kinase complexes with type II receptors.