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- Table of Contents
AFAP1 Antibodies
AND AFAP1 ELISA kits, AFAP1 Proteins
Many biological assays use antibodies to detect AFAP1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with AFAP1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop AFAP1 antibodies...
Designing a Western blot for AFAP1? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the AFAP1 Western Blot GuideAFAP1 Infographic by Boster Bio
All AFAP1 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
ELISA, Flow Cytometry, IHC, WB
$370
Cat # A05258-3
100 μg/vial
Cat # A05258-3
100 μg/vial
Human, Mouse, Rat
IHC, WB
$523
Cat # M05258
100 µl
Cat # M05258
100 µl
AFAP1 Overview
Facts about Actin filament-associated protein 1.
Actin filament-associated protein 1 (AFAP1)
Can cross-link actin filaments into both network and package structures (By similarity). May regulate changes in actin filament integrity and cause lamellipodia formation.
May function as an adapter molecule that links other proteins, such as SRC and PKC to the actin cytoskeleton. Seems to play a role in the development and progression of prostate adenocarcinoma by regulating cell-matrix adhesions and migration in the cancer cells.
Gene Information
| Human | |
|---|---|
| Gene Name: | AFAP1 |
| Uniprot: | Q8N556 |
| Entrez: | 60312 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
actin filament associated protein 1; AFAP; AFAP1; AFAP-110; FLJ56849
Molecular Weight
Mass (kDA):
80.725 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 4p16.1 |
| Sequence: | 4; NC_000004.12 (7758713..7939926, complement) |
Tissue Specificity
Low expression in normal breast epithelial cell line MCF-10A and in tumorigenic breast cancer cell lines MCF- 7, T-47D and ZR-75-1. Highly expressed in the invasive breast cancer cell lines MDA-MB-231 and MDA-MB-435. Overexpressed in prostate carcinoma.
Subcellular Localizations
Cytoplasm, cytoskeleton, stress fiber.
Diseases
- Myopathy
- Neuroblastoma
- Neoplasm Metastasis
- Malignant Neoplasms
- Fetal Diseases
- Neuromuscular Diseases
Pathways
- Cell Proliferation
- Cellular Localization
- Cell Motility
- Intracellular Signal Transduction
- Localization
PTMs
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/AFAP1
bosterbio.com/bosterbio-gene-info-cards/AFAP1
References
PMID: 15485829 by Han B., et al. Conversion of mechanical force into biochemical signaling.
PMID: 17520695 by Dorfleutner A., et al. AFAP-110 is required for actin stress fiber formation and cell adhesion in MDA-MB-231 breast cancer cells.