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From the pancreatic and salivary ducts, at resting state, attenuates inositol 1,4,5- trisphosphate-induced calcium release by interacting with ITPR1 (PubMed:16793548). When extracellular stimuli induce ITPR1 phosphorylation or inositol 1,4,5-trisphosphate production, dissociates of ITPR1 to interact with CFTR and SLC26A6 mediating their synergistic activation by calcium and cAMP that stimulates the epithelial secretion of electrolytes and fluid (By similarity).
|Sequence:||1; NC_000001.11 (109984765..110023742)|
Expressed in dendritic cells.
Endoplasmic reticulum. Cytoplasm, cytosol. Microsome. Apical cell membrane. Associates with membranes when phosphorylated, probably through interaction with ITPR1.