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- Table of Contents
Facts about S-adenosylhomocysteine hydrolase-like protein 1.
From the pancreatic and salivary ducts, at resting state, attenuates inositol 1,4,5- trisphosphate-induced calcium release by interacting with ITPR1 (PubMed:16793548). When extracellular stimuli induce ITPR1 phosphorylation or inositol 1,4,5-trisphosphate production, dissociates of ITPR1 to interact with CFTR and SLC26A6 mediating their synergistic activation by calcium and cAMP that stimulates the epithelial secretion of electrolytes and fluid (By similarity).
Human | |
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Gene Name: | AHCYL1 |
Uniprot: | O43865 |
Entrez: | 10768 |
Belongs to: |
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adenosylhomocysteinase family |
adenosylhomocysteinase-like 1; AdoHcyase 2; DCAL; DC-expressed AHCY-like molecule; dendritic cell expressed AHCY-like protein; inositol 14,5-trisphosphate receptor-binding protein; IRBIT; PRO0233; putative adenosylhomocysteinase 2; S-adenosyl homocysteine hydrolase homolog; S-adenosylhomocysteine hydrolase-like 1; S-adenosylhomocysteine hydrolase-like protein 1; S-adenosyl-L-homocysteine hydrolase 2; XPVKONAEC 3.3.1.1
Mass (kDA):
58.951 kDA
Human | |
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Location: | 1p13.3 |
Sequence: | 1; NC_000001.11 (109984765..110023742) |
Expressed in dendritic cells.
Endoplasmic reticulum. Cytoplasm, cytosol. Microsome. Apical cell membrane. Associates with membranes when phosphorylated, probably through interaction with ITPR1.
This article provides an overview of Boster Bio's AHCYL1 Primary Antibody and the AHCYL1 Marker. Boster provides primary antibodies that are highly affinity and have been cited in numerous publications. In addition, these antibodies are validated for use in Western Blotting, Immunohistochemistry, and ELISA. This makes them the most trusted antibody in the research community.
For researchers, Boster Bio offers primary antibodies that are high in affinity and sensitivity. Boster Bio has developed highly validated antibodies that can be used for ELISA, WB or Flow Cytometry assays. They come with a Boster Guarantee of Quality and are guaranteed that they will work as described. They include antibodies for many applications, including neuroscience, biomedical and forensics.
Boster also offers high-affinity primary antibodies and other biomarker immunoassays. PicoKine(tm), a proprietary ELISA platform that detects cancer biomarkers at picogram-level sensitivity, is available from Boster. Boster Bio manufactures its antibodies, ELISA kits and other products in its own facilities to maintain its high quality standards. All products have been optimized for maximum sensitivity. This saves up to 30 minutes in sample preparation.
Flow cytometry offers many benefits beyond the benefits of ELISA. It is also useful in medicine, biology and other fields. Primary antibodies are immunoglobulins able to bind specifically to an antigen. Quality primary antibodies will have high affinity to the targeted antigen. They will also have high affinity for the antigen they are measuring.
Secondary antibodies are versatile and useful tools for scientists. These antibodies are usually conjugated to other molecules to enable them to react with a range of other compounds. Secondary antibodies are good for dual labeling. It will allow researchers more information and enable them to ask more questions. Secondary antibodies can detect multiple targets from a single sample, which is not possible with primary antibodies. Therefore, this option is particularly useful for immunoassays.
The AHCYL1 marker is a highly specific gene which is used in various studies to detect certain types of agronomic problems. The protein can detect the presence of classical and nodular Lymphocytes. As a result, it can be used to discriminate between two types of Hodgkin lymphoma. Its high affinity, versatility and adaptability make it ideal for many applications.
AHCY (a protein found in cells) is a cofactor of RNA polymerase 2 and mRNA (7-7) methyltransferase. The protein plays an important role in many cellular functions, including embryonic and developmental development. This gene is essential to many processes, including embryonic stem cell development and immune system regulation. Direct testing is difficult as there are currently no cell types that express this gene.
AHCYL1 interacts in synaptic interactions, which affects neuronal functions. It is also involved in ion channel trafficking and may be involved in SCI progression. Kawaai (et al.) found that mice with this gene had increased locomotor activity in mice. This could be a sign of neuronal function.
AHCYL1 has been conserved in many species including chicken. Chickens and mammalian species also express this gene. AHCYL1 acts as a tumor suppressor. Therefore, its use in human research has increased. There are many uses for AHCYL1 gene. The protein is used for the identification of cancer cells in mice and mammalian species. Below are the best uses this gene marker has.
The AHCYL1 gene encodes a novel intracellular protein with 50% amino acid identity with AHCY, an important enzyme in the methylation pathway. AHCYL1 binds an inositol 1-4,5-triphosphate (I1TP) receptor and may regulate intracellular calcium production. Bioinformatics research revealed AHCYL1 orthologs within vertebrates. While these proteins are highly conserved throughout species, the gene and protein evolved independently of each other.
Functional mechanisms of the chicken oviducts are associated with AHCYL1. It may also play a role in calcium metabolism for egg shell development. It is not known what AHCYL1 does in humans. The immune microenvironment, which includes the AHCYL1 genetic component, is important. It is also associated wit tumor growth. Its importance in cancer research remains unknown.
5'RACE is used for the study of AHCYL1 gene expression. One mg total RNA was taken from the adult zebrafish skull using a Thermoscript RTPCR machine to create the cDNA. The resulting cDNA sequences are orthologs of the hAHCYL1 gene. Numerous studies have confirmed its presence in zebrafish.
Steve Boster, a Joliet, Illinois resident was born June 6, 1932. He was the son James Boster's and Evelyn Meier's child. He was a former retail salesman and a member Concordia Hall, Staunton, VA. Frances, his wife of 62 years, two daughters Natosha Poeck and Crystal Boster are his survivors. 6 grandchildren, 4 brother Jack and Steve and many nieces & nephews are also his legacy.
Steve loved his family and was the first to call. He would call first if his car had broken down at 2 AM and show up to appointments in subzero conditions. He treated his close friends like family. His life has many historical landmarks. Here are some facts about Steven Boster.
PMID: 11904675 by Dekker J.W., et al. Identification of an S-adenosylhomocysteine hydrolase-like transcript induced during dendritic cell differentiation.
PMID: 12878157 by Imabayashi H., et al. Redifferentiation of dedifferentiated chondrocytes and chondrogenesis of human bone marrow stromal cells via chondrosphere formation with expression profiling by large-scale cDNA analysis.