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- Table of Contents
Facts about Microtubule organization protein AKNA.
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Human | |
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Gene Name: | AKNA |
Uniprot: | Q7Z591 |
Entrez: | 80709 |
Belongs to: |
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AKNA family |
AKNA transcript F2; AT-hook transcription factor AKNA; AT-hook transcription factor; AT-hook-containing transcription factor; FLJ31001; FLJ33184; KIAA1968RP11-82I1.4
Mass (kDA):
155.139 kDA
Human | |
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Location: | 9q32 |
Sequence: | 9; NC_000009.12 (114334149..114398498, complement) |
Predominantly expressed by lymphoid tissues. Highly expressed in the spleen, lymph nodes and peripheral blood leukocytes, expressed at lower level in the thymus. Mainly expressed by germinal center B-lymphocytes, a stage in which receptor and ligand interactions are crucial for B-lymphocyte maturation. Expressed by B- and T-lymphocytes, Natural killer cells and CD1a(+)CD14(-) but not CD1a(-)CD14(+) dendritic cells. Weakly or not expressed in fetal liver and in adult bone marrow.
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Nucleus. Localizes to the distal part of the subdistal appendages of the mother centriole in interphase. Also found at the proximal ends of centrioles and along microtubules. The centrosomal localization is dependent on centrioles. Dissociates from centrosomes during M-phase without proteolytic degradation and reassembles at the centrosomes during late telophase and early G1 phase. Dissociation and reassembly is regulated by phosphorylation.
PMID: 15869410 by Sims-Mourtada J.C., et al. The human AKNA gene expresses multiple transcripts and protein isoforms as a result of alternative promoter usage, splicing, and polyadenylation.
PMID: 11268217 by Siddiqa A., et al. Regulation of CD40 and CD40 ligand by the AT-hook transcription factor AKNA.