Homeobox protein ESX1 (ESX1)

May coordinately regulate cell cycle progression and transcription during spermatogenesis. Inhibits degradation of polyubiquitinated cyclin A and cyclin B1 and thereby arrests the cell cycle at early M phase.

ESXR1-N functions as a transcriptional repressor. Binds to the sequence 5'-TAATGTTATTA-3' that is present within the first intron of the KRAS gene and inhibits its expression.