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- Table of Contents
Facts about Homeobox protein ESX1.
ESXR1-N functions as a transcriptional repressor. Binds to the sequence 5'-TAATGTTATTA-3' that is present within the first intron of the KRAS gene and inhibits its expression.
| Human | |
|---|---|
| Gene Name: | ESX1 |
| Uniprot: | Q8N693 |
| Entrez: | 80712 |

| Belongs to: |
|---|
| No superfamily |

ESX homeobox 1; ESX1LESX1R; ESX1-related protein; ESXR1homeobox protein ESX1; extraembryonic, spermatogenesis, homeobox 1 homolog (mouse); extraembryonic, spermatogenesis, homeobox 1 homolog; Extraembryonic, spermatogenesis, homeobox 1
Mass (kDA):
44.297 kDA

| Human | |
|---|---|
| Location: | Xq22.2 |
| Sequence: | X; NC_000023.11 (104250038..104254933, complement) |
Expressed in placenta and testis. Expressed in testicular germ cell tumors.
Cytoplasm. Nucleus. ESXR1-N localizes specifically to the nucleus while ESXR1-C localizes specifically to the cytoplasm.




PMID: 11374906 by Fohn L.E., et al. ESX1L, a novel X chromosome-linked human homeobox gene expressed in the placenta and testis.
PMID: 15235584 by Ozawa H., et al. Paired-like homeodomain protein ESXR1 possesses a cleavable C- terminal region that inhibits cyclin degradation.