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- Table of Contents
AKR1C2 Antibodies
AND AKR1C2 ELISA kits, AKR1C2 Proteins
Many biological assays use antibodies to detect AKR1C2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with AKR1C2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop AKR1C2 antibodies...
Designing a Western blot for AKR1C2? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the AKR1C2 Western Blot GuideAKR1C2 Infographic by Boster Bio
All AKR1C2 Products
Product
Figures
Specificity
Applications
Price
Anti-AKR1C1/C2 Antibody Picoband®
1 Citations
Human, Mouse, Rat
Flow Cytometry, IF, ICC, WB
$370
Cat # PB10036
100 μg/vial
Cat # PB10036
100 μg/vial
Anti-AKR1C1 / AKR1C2 Rabbit Monoclonal Antibody
1 Citations
Human, Mouse, Rat
Flow Cytometry, WB
$370
Cat # M03056-1
100 μl/vial
Cat # M03056-1
100 μl/vial
AKR1C2 Overview
Facts about Aldo-keto reductase family 1 member C2.
Aldo-keto reductase family 1 member C2 (AKR1C2)
Works in concert with the 5-alpha/5-beta-steroid reductases to convert steroid hormones to the 3-alpha/5-alpha and 3-alpha/5-beta-tetrahydrosteroids. Catalyzes the inactivation of the most potent androgen 5-alpha-dihydrotestosterone (5-alpha- DHT) into 5-alpha-androstane-3-alpha,17-beta-diol (3-alpha-diol).
Has a top bile-binding ability. .
Gene Information
| Human | |
|---|---|
| Gene Name: | AKR1C2 |
| Uniprot: | P52895 |
| Entrez: | 1646 |
Family
| Belongs to: |
|---|
| aldo/keto reductase family |
Alternative Names
aldo-keto reductase family 1 member C2; aldo-keto reductase family 1, member C2 (dihydrodiol dehydrogenase 2; bile acidbinding protein; 3-alpha hydroxysteroid dehydrogenase, type III); BABP; Chlordecone reductase homolog HAKRD; DD; DD-2; DD2DD/BABP; DDH2FLJ53800; Dihydrodiol dehydrogenase 2; Dihydrodiol dehydrogenase/bile acid-binding protein; EC 1.1.1,3-alpha-HSD3; EC 1.1.1.213; EC 1.3.1.20; HAKRDAKR1C-pseudo; HBAB; MCDR2; pseudo-chlordecone reductase; Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase; type II dihydrodiol dehydrogenase; Type III 3-alpha-hydroxysteroid dehydrogenase
Molecular Weight
Mass (kDA):
36.735 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 10p15.1 |
| Sequence: | 10; NC_000010.11 (4987775..5018033, complement) |
Tissue Specificity
Expressed in fetal testes. Expressed in fetal and adult adrenal glands.
Subcellular Localizations
Cytoplasm.
Diseases
- Malignant Neoplasms
- Neoplasms
- Malignant Neoplasm Of Prostate
- Malignant Neoplasm Of Breast
- Carcinoma
- Prostatic Neoplasms
- Cholestasis
- Liver Carcinoma
- Mammary Neoplasms
- Adenocarcinoma
- Obesity
- Malignant Tumor Of Colon
- Carcinogenesis
Pathways
- Transport
- Secretion
- Cell Proliferation
- Localization
- Excretion
- Conjugation
- Drug Resistance
- Intracellular Transport
- Parturition
- Pathogenesis
- Cholesterol Homeostasis
- Intestinal Absorption
- Cell Cycle
PTMs
- Phosphorylation
- Reduction
- Cleavage
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/AKR1C2
bosterbio.com/bosterbio-gene-info-cards/AKR1C2
References
PMID: 8274401 by Qin K.-N., et al. Molecular cloning of multiple cDNAs encoding human enzymes structurally related to 3 alpha-hydroxysteroid dehydrogenase.
PMID: 8011662 by Ciaccio P.J., et al. cDNA and deduced amino acid sequences of a human colon dihydrodiol dehydrogenase.