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- Table of Contents
Facts about Aldehyde dehydrogenase family 1 member A3.
Required for the biosynthesis of normal levels of retinoic acid in the embryonic ocular and nasal areas; retinoic acid is required for normal embryonic development of the eye and the nasal region (By similarity). .
Human | |
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Gene Name: | ALDH1A3 |
Uniprot: | P47895 |
Entrez: | 220 |
Belongs to: |
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aldehyde dehydrogenase family |
aldehyde dehydrogenase 1 family, member A3; Aldehyde dehydrogenase 6; aldehyde dehydrogenase family 1 member A3; ALDH1A6; ALDH6acetaldehyde dehydrogenase 6; EC 1.2.1; EC 1.2.1.5; RALDH3; RALDH-3; Retinaldehyde dehydrogenase 3
Mass (kDA):
56.108 kDA
Human | |
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Location: | 15q26.3 |
Sequence: | 15; NC_000015.10 (100879831..100916626) |
Expressed at low levels in many tissues and at higher levels in salivary gland, stomach, and kidney.
Cytoplasm.
PMID: 7698756 by Hsu L.C., et al. Molecular cloning, genomic organization, and chromosomal localization of an additional human aldehyde dehydrogenase gene, ALDH6.
PMID: 23591992 by Yahyavi M., et al. ALDH1A3 loss of function causes bilateral anophthalmia/microphthalmia and hypoplasia of the optic nerve and optic chiasm.