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- Table of Contents
Facts about Fructose-bisphosphate aldolase B.
Human | |
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Gene Name: | ALDOB |
Uniprot: | P05062 |
Entrez: | 229 |
Belongs to: |
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class I fructose-bisphosphate aldolase family |
ALDO2; aldolase B, fructose-bisphosphate; EC 4.1.2.13; fructose-bisphosphatase; fructose-bisphosphate aldolase B
Mass (kDA):
39.473 kDA
Human | |
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Location: | 9q31.1 |
Sequence: | 9; NC_000009.12 (101420560..101435774, complement) |
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite.
Boster Bio has been producing antibodies for over 25 year and all of their primary antibodies have been referenced extensively in the research community. Boster antibodies have been tested and validated for their efficacy on immunohistochemistry, Western Blotting, and ELISA. This means you can count on their quality and reliability. Read on to learn more about Boster Bio: Best Uses of the ALDOB Marker
Polyclonal antibodies are primary high-affinity antibodies, also known as polyclonal antibodies. They are created by immunizing host animal with specific antigens. Scientists then isolate antibodies from the host's sera and eggs. These primary antibodies are highly specific and possess an extremely high affinity. Their quality cannot be assured. If you are not sure about the quality of the product then contact Sanbio. They'll be happy to discuss your needs. Contact us if not sure if Boster Bio High Affinity Primary Antibodies are right for you.
High-affinity primary antibodies from Boster Bio are designed to provide the highest levels of specificity and sensitivity. Developed over the past two decades, they have proven themselves in the research community with validated results in Western Blotting, Immunohistochemistry, and ELISA. Boster antibodies are well-known for their superiority and have been referenced in more than 29,000 papers. The Boster antibodies have been tested against several proteins and are widely utilized in research.
In addition to primary antibodies, Boster has a series of other reagents used in immunoassays. They contain a range of secondary antibodies that can be used as core components of experiments and tests. In immunoassays, antibodies' ability to bind antigens is assessed using an enzyme-mediated immunoassay. This involves the use of ELISA (Enzyme-Linked Immunosorbent Assay)--a type of test that determines the quantity of specific cell kinds.
Despite the high affinity of monoclonal antibodies, the biological mechanisms that govern the formation of these proteins are unexplored. The physiological temperature for B cell maturation limits and the rate of receptor internalization upon Ag binding are important factors in determining the limits of affinity. These biological constants are useful in basic immunological science as well as discovery of drugs. It is crucial to know that the Boster Bio High-affinity antibodies are based on a variety of collection of monoclonal sera.
Cloning Ab genes from human cells has provided fresh insights into the molecular structure of the Ab response. The limits of repertoire diversification remain unidentified however, it is possible to measure progression of Ab repertoires in people who are frequently exposed to invariant B cells Ag. These limitations provide insight into the fundamental characteristics of the adaptive immune system, and they are important for the development of Ab-based drugs and vaccines.
ALDOB, also known as aldolase, is a gene that provides instructions for the creation of an enzyme that breaks down various molecules that are found in cells. Four identical copies of the gene constitute a tetramerand need to be linked to function correctly. This article will examine some of the consequences of having this gene. We will also discuss the importance of this marker in research.
This gene is associated with numerous diseases such as hereditary glycolysis fatty acids, fructose pyrophosphate intolerance diabetes, and hereditary glycocation. ALDOB is involved with glycolysis (BIOCYC), fructose metabolism, and with related pathways like glycolysis and ATPase binding. Gene informationgraphics for the ALDOB marker provide the genome location for this protein in the UCSC Genome Browser.
The History of the ALDOB Marker is a fascinating one. The protein is widely expressed in CRC and has an inverse correlation with tumor stage. This is what makes ALDOB an attractive candidate for the use of biomarkers in CRC. What is it? Here's a closer look the protein. And what's the most exciting thing about this marker? It may just be the next big thing for cancer research!
This protein induces colon cancer cells to undergo an epithelial-mesenchymal transition. The researchers used LoVo and SW480 cells which were transfected with scramble sequences or sgRNAs against ALDOB. As an experiment, they measured b-actin levels. They discovered that silencing ALDOB reduced colon cancer cell invasion and proliferation. ALDOB was also proven to regulate mesenchymal markers like Ncadherin and vimentin.
The history of the ALDOB gene began when researchers first discovered two mutations in the protein. One of these mutations, c.448G>C, (p.Ala175Asp) causes ALDOB to be affected. It also causes an increased expression of CD44. Additionally to this, high CD44 levels are also associated with poorer survival. Low DFS and OS are frequently related to high CEA levels.
PMID: 6548561 by Paolella G., et al. Isolation and nucleotide sequence of a full-length cDNA coding for aldolase B from human liver.
PMID: 2410860 by Sakakibara M., et al. Human aldolase isozyme gene: the structure of multispecies aldolase B mRNAs.