This website uses cookies to ensure you get the best experience on our website.
- Table of Contents
AMFR Antibodies
AND AMFR ELISA kits, AMFR Proteins
Many biological assays use antibodies to detect AMFR, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with AMFR in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop AMFR antibodies...
Designing a Western blot for AMFR? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the AMFR Western Blot GuideAMFR Infographic by Boster Bio
All AMFR Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # PB10039
100 μg/vial
Cat # PB10039
100 μg/vial
AMFR Overview
Facts about E3 ubiquitin-protein ligase AMFR.
E3 ubiquitin-protein ligase AMFR (AMFR)
E3 ubiquitin-protein ligase that mediates the polyubiquitination of a number of proteins like CD3D, CYP3A4, CFTR and APOB for proteasomal degradation. Component of a VCP/p97- AMFR/gp78 complex that participates in the last step of endoplasmic reticulum-associated degradation (ERAD).
The VCP/p97- AMFR/gp78 complex is included in the sterol-accelerated ERAD degradation of HMGCR through binding to the HMGCR-INSIG complicated at the ER membrane and initiating ubiquitination of HMGCR. The ubiquitinated HMGCR is subsequently released from the ER from the complex into the cytosol for subsequent destruction.
Gene Information
| Human | |
|---|---|
| Gene Name: | AMFR |
| Uniprot: | Q9UKV5 |
| Entrez: | 267 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
AMF receptor; AMF receptor, isoform 1; AMF receptor, isoform 2; AMFR; autocrine motility factor receptor; Autocrine motility factor receptor, isoform 2; gp78; RING finger protein 45; RNF45; RNF45EC 6.3.2.-
Molecular Weight
Mass (kDA):
72.996 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 16q13 |
| Sequence: | 16; NC_000016.10 (56361452..56425545, complement) |
Subcellular Localizations
Endoplasmic reticulum membrane; Multi-pass membrane protein. Palmitoylation promotes localization to the peripheral endoplasmic reticulum.
Diseases
- Neoplasms
- Neoplasm Metastasis
- Malignant Neoplasms
- Cell Invasion
- Carcinoma
- Tumor Progression
- Neoplasm Invasiveness
- Tissue Adhesions
- Lung Neoplasms
- Malignant Paraganglionic Neoplasm
- Malignant Neoplasm Of Lung
- Malignant Squamous Cell Neoplasm
- Metastatic Malignant Neoplasm To The Lymph Node
Interacting Proteins
- ERLIN2
- INSIG1
- UBE2G2
- Ube2g2
- VCP
Pathways
- Cell Motility
- Cell Migration
- Secretion
- Localization
- Angiogenesis
- Locomotion
- Endocytosis
- Rna Interference
- Transport
- Aging
- Cell Adhesion
- Cell Proliferation
- Pathogenesis
PTMs
- Ubiquitination
- Phosphorylation
- Glycosylation
- Cleavage
Research Areas
- Zinc Finger
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/AMFR
bosterbio.com/bosterbio-gene-info-cards/AMFR
References
PMID: 10456327 by Shimizu K., et al. The autocrine motility factor receptor gene encodes a novel type of seven transmembrane protein.
PMID: 7626106 by Huang B., et al. Identification of an upstream region that controls the transcription of the human autocrine motility factor receptor.