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- Table of Contents
Annexin A2 Antibodies
AND ANXA2 ELISA kits, Annexin A2 Proteins
Many biological assays use antibodies to detect Annexin A2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Annexin A2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Annexin A2 antibodies...
Designing a Western blot for Annexin A2? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the ANXA2 Western Blot GuideDesigning an IHC experiment for Annexin A2? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.
Open the ANXA2 IHC GuideANXA2 Infographic by Boster Bio
All ANXA2 Products
Product
Figures
Specificity
Applications
Price
Anti-Annexin A2/ANXA2 Antibody Picoband®
1 Citations
Human, Mouse, Rat
Flow Cytometry, IHC, WB
$370
Cat # PA1348
100 μg/vial
Cat # PA1348
100 μg/vial
Human, Mouse, Rat
Flow Cytometry, WB
$370
Cat # A00868-1
100 μg/vial
Cat # A00868-1
100 μg/vial
Human, Mouse, Rat
Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # M00868
100 μl
Cat # M00868
100 μl
Human
$628
Cat # LS000302
20 µg, 100 µg
Cat # LS000302
20 µg, 100 µg
ANXA2 Overview
Facts about Annexin A2.
Annexin A2 (ANXA2)
Calcium-regulated membrane-binding protein affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity.
May be involved in heat-stress reaction. Inhibits PCSK9-enhanced LDLR degradation, probably reduces PCSK9 protein levels via a translational mechanism but also competes with LDLR for binding with PCSK9 (PubMed:18799458, PubMed:24808179, PubMed:22848640).
Gene Information
| Human | |
|---|---|
| Gene Name: | ANXA2 |
| Uniprot: | P07355 |
| Entrez: | 302 |
Family
| Belongs to: |
|---|
| annexin family |
Alternative Names
Annexin A2; Annexin II; annexin-2; ANX2; ANX2L4; ANX2L4LPC2; ANXA2; CAL1H; Calpactin I heavy chain; calpactin I heavy polypeptide; Calpactin-1 heavy chain; chromobindin 8; chromobindin-8; LIP2; LIP2PAP-IV; Lipocortin II; Lipocortin-2; LPC2D; LPC2DP36; p36; PAP-IV; Placental anticoagulant protein IV; Protein I
Molecular Weight
Mass (kDA):
38.604 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 15q22.2 |
| Sequence: | 15; NC_000015.10 (60347151..60398025, complement) |
Subcellular Localizations
Secreted, extracellular space, extracellular matrix, basement membrane. Melanosome. In the lamina beneath the plasma membrane. Identified by mass spectrometry in melanosome fractions from stage I to stage IV. Translocated from the cytoplasm to the cell surface through a Golgi-independent mechanism.
Diseases
- Malignant Neoplasms
- Neoplasms
- Neoplasm Metastasis
- Carcinoma
- Cell Invasion
- Tissue Adhesions
- Malignant Paraganglionic Neoplasm
- Inflammation
- Leukemia
- Neoplasm Invasiveness
- Tumor Angiogenesis
- Acute Promyelocytic Leukemia
- Liver Carcinoma
Interacting Proteins
- ANG
- CCR10
- MLH1
- PCNA
- PCSK9
- POT1
- S100A10
Pathways
- Transport
- Localization
- Pathogenesis
- Fibrinolysis
- Angiogenesis
- Secretion
- Cell Proliferation
- Endocytosis
- Cell Migration
- Exocytosis
- Rna Interference
- Immune Response
- Cell Death
PTMs
- Phosphorylation
- Cleavage
- Biotinylation
- Reduction
Research Areas
- Cancer
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/ANXA2
bosterbio.com/bosterbio-gene-info-cards/ANXA2
References
PMID: 3013422 by Huang K.-S., et al. Two human 35 kd inhibitors of phospholipase A2 are related to substrates of pp60v-src and of the epidermal growth factor receptor/kinase.
PMID: 2174397 by Spano F., et al. Characterization of the human lipocortin-2-encoding multigene family: its structure suggests the existence of a short amino acid unit undergoing duplication.
1 Publications of Boster Annexin A2 Antibodies & ELISA Kits
- PubMed ID: 22202185, Zhu J, Zou W, Jia G, Zhou H, Hu Y, Peng M, Chen H, Jin M. J Proteomics. 2012 Mar...
*More publications can be found for each product on its corresponding product page