Annexin A2 (ANXA2)

Calcium-regulated membrane-binding protein affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity.

May be involved in heat-stress reaction. Inhibits PCSK9-enhanced LDLR degradation, probably reduces PCSK9 protein levels via a translational mechanism but also competes with LDLR for binding with PCSK9 (PubMed:18799458, PubMed:24808179, PubMed:22848640).