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- Table of Contents
APBB1 Antibodies
AND APBB1 ELISA kits, APBB1 Proteins
Many biological assays use antibodies to detect APBB1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with APBB1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop APBB1 antibodies...
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APBB1 Infographic by Boster Bio
All APBB1 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
WB
$523
Cat # M03090
100 µl
Cat # M03090
100 µl
APBB1 Overview
Facts about Amyloid-beta A4 precursor protein-binding family B member 1.
Amyloid-beta A4 precursor protein-binding family B member 1 (APBB1)
Transcription coregulator that could have both coactivator and corepressor functions. Adapter protein which forms a transcriptionally active complex with the gamma-secretase-derived amyloid precursor protein (APP) intracellular domain.
Plays a central role in the response to DNA damage by translocating to the nucleus and causing apoptosis. May act by specifically recognizing and binding histone H2AX phosphorylated on'Tyr-142' (H2AXY142ph) in double-strand breaks (DSBs), recruiting other pro- apoptosis factors such as MAPK8/JNK1.
Gene Information
| Human | |
|---|---|
| Gene Name: | APBB1 |
| Uniprot: | O00213 |
| Entrez: | 322 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
adaptor protein FE65a2; amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65); amyloid beta A4 precursor protein-binding, family B, member 1; Fe65; FE65amyloid beta A4 precursor protein-binding family B member 1; MGC:9072; Protein Fe65; RIR; stat-like protein
Molecular Weight
Mass (kDA):
77.244 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 11p15.4 |
| Sequence: | 11; NC_000011.10 (6395124..6419453, complement) |
Tissue Specificity
Highly expressed in brain; strongly reduced in post-mortem elderly subjects with Alzheimer disease.
Subcellular Localizations
Cell membrane. Cytoplasm. Nucleus. Cell projection, growth cone. Nucleus speckle. Colocalizes with TSHZ3 in axonal growth cone (By similarity). In normal conditions, it mainly localizes to the cytoplasm, while a small fraction is tethered to the cell membrane via its interaction with APP. Following exposure to DNA damaging agents, it is released from cell membrane and translocates to the nucleus. Nuclear translocation is under the regulation of APP. Colocalizes with TSHZ3 in the nucleus. Colocalizes with NEK6 at the nuclear speckles. Phosphorylation at Ser-610 by SGK1 promotes its localization
Diseases
- Alzheimer's Disease
- Nervousness
- Dementia
- Senile Plaques
- Neurodegenerative Disorders
- Neuroblastoma
- Neurotoxicity Syndromes
- Neoplasms
- Dysequilibrium Syndrome
- Dental Plaque
- Plaque, Amyloid
- Alzheimer Disease, Familial
- Malnutrition
Interacting Proteins
- APP
- ARF6
- EGFR
- ERBB2
- LRP1
- Sv2a
Pathways
- Pathogenesis
- Localization
- Secretion
- Proteolysis
- Cell Death
- Brain Development
- Transport
- Aging
- Neurogenesis
- Protein Processing
- Translation
- Cell Cycle
- Cell Motility
PTMs
- Cleavage
- Phosphorylation
- Gamma-cleavage
Research Areas
- Alzheimers Research
- Cell Cycle and Replication
- Neurodegeneration
- Neuroscience
- Signal Transduction
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/APBB1
bosterbio.com/bosterbio-gene-info-cards/APBB1
References
PMID: 8894693 by Bressler S.L., et al. cDNA cloning and chromosome mapping of the human Fe65 gene: interaction of the conserved cytoplasmic domains of the human beta- amyloid precursor protein and its homologues with the mouse Fe65 protein.
PMID: 9799084 by Hu Q., et al. The human FE65 gene: genomic structure and an intronic biallelic polymorphism associated with sporadic dementia of the Alzheimer type.