APBB1 Antibodies

Amyloid-beta A4 precursor protein-binding family B member 1 (APBB1)

Transcription coregulator that could have both coactivator and corepressor functions. Adapter protein which forms a transcriptionally active complex with the gamma-secretase-derived amyloid precursor protein (APP) intracellular domain.

Plays a central role in the response to DNA damage by translocating to the nucleus and causing apoptosis. May act by specifically recognizing and binding histone H2AX phosphorylated on'Tyr-142' (H2AXY142ph) in double-strand breaks (DSBs), recruiting other pro- apoptosis factors such as MAPK8/JNK1.

Gene Information

Human
Gene Name:	APBB1
Uniprot:	O00213
Entrez:	322

Family

Belongs to:
No superfamily

Alternative Names

adaptor protein FE65a2; amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65); amyloid beta A4 precursor protein-binding, family B, member 1; Fe65; FE65amyloid beta A4 precursor protein-binding family B member 1; MGC:9072; Protein Fe65; RIR; stat-like protein

Molecular Weight

Mass (kDA):
77.244 kDA

Genomic Context

Human
Location:	11p15.4
Sequence:	11; NC_000011.10 (6395124..6419453, complement)

Tissue Specificity

Highly expressed in brain; strongly reduced in post-mortem elderly subjects with Alzheimer disease.

Subcellular Localizations

Cell membrane. Cytoplasm. Nucleus. Cell projection, growth cone. Nucleus speckle. Colocalizes with TSHZ3 in axonal growth cone (By similarity). In normal conditions, it mainly localizes to the cytoplasm, while a small fraction is tethered to the cell membrane via its interaction with APP. Following exposure to DNA damaging agents, it is released from cell membrane and translocates to the nucleus. Nuclear translocation is under the regulation of APP. Colocalizes with TSHZ3 in the nucleus. Colocalizes with NEK6 at the nuclear speckles. Phosphorylation at Ser-610 by SGK1 promotes its localization

Diseases

• Alzheimer's Disease
• Nervousness
• Dementia
• Senile Plaques
• Neurodegenerative Disorders
• Neuroblastoma
• Neurotoxicity Syndromes
• Neoplasms
• Dysequilibrium Syndrome
• Dental Plaque
• Plaque, Amyloid
• Alzheimer Disease, Familial
• Malnutrition

• Down Syndrome
• Carcinoma
• Neurofibrillary Tangles
• Neuropathology Disease
• Genotoxic Stress
• Parkinson Disease
• Memory Disorders

Interacting Proteins

• APP
• ARF6
• EGFR
• ERBB2
• LRP1

• Sv2a

Pathways

• Pathogenesis
• Localization
• Secretion
• Proteolysis
• Cell Death
• Brain Development
• Transport
• Aging
• Neurogenesis
• Protein Processing
• Translation
• Cell Cycle
• Cell Motility

• Dna Repair
• Synaptic Transmission
• Cell Adhesion
• Hyperphosphorylation
• Cell Migration
• Protein Biotinylation
• Protein Maturation

PTMs

• Cleavage
• Phosphorylation
• Gamma-cleavage

• Acetylation
• Biotinylation
• Glycosylation

• Ubiquitination

Research Areas

• Alzheimers Research
• Cell Cycle and Replication
• Neurodegeneration
• Neuroscience
• Signal Transduction

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/APBB1

Best Uses Of The APBB1 Marker

Boster Bio offers a variety products to suit your needs. Boster has been a trusted supplier of primary antibodies for over 25 years, and their products have been validated on ELISA, Western Blotting, and Immunohistochemistry.

Boster Bio's high-affinity prima antibodies

The APBB1 marker has been identified as a potential therapeutic target in a variety of disorders. The protein possesses an amino acid sequence that matches the APBB1 marker. The protein is also known by human TfR1. The APBB1 markers are a marker that identifies human TfR1.

PICOKINE(tm), ELISA kit

Picokine(tm), ELISA kits are designed for reducing non-specific binding and increasing the binding efficiency of capture antibody. The resulting sensitivity can be as low as one picogram. The ELISA kits are tested at 37degC over a week before release and contain enough reagents for 96 tests. They are highly sensitive, specific, and have been validated for a wide variety samples. This product line is available through tebubio.

Several companies offer ELISA Kits for the APBB1/TTP–Cas9 Protein. There are many antibodies that can be used to detect and quantify APBB1 within samples. Some of these antibody are specific to rat, mouse, or human. These kits can help in diagnosing the underlying causes of Alzheimer's disease.

APBB1 marker

Every mammal has the APBB1 gene. This gene is involved in the regulation of a number of different processes, including development and cell growth. Molecular biology studies can help identify disease-causing genes, and the APBB1 marker can be used to detect it. Researchers can find many antibodies in this marker type. Boster’s APBB1 antibody may be used in a variety research applications.