APRT Antibodies

Adenine phosphoribosyltransferase (APRT)

Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. .

Gene Information

Human
Gene Name:	APRT
Uniprot:	P07741
Entrez:	353

Family

Belongs to:
purine/pyrimidine phosphoribosyltransferase family

Alternative Names

adenine phosphoribosyltransferase; AMP diphosphorylase; AMP pyrophosphorylase; AMP; DKFZp686D13177; EC 2.4.2.7; MGC125856; MGC125857; MGC129961; transphosphoribosidase

Molecular Weight

Mass (kDA):
19.608 kDA

Genomic Context

Human
Location:	16q24.3
Sequence:	16; NC_000016.10 (88809339..88811928, complement)

Subcellular Localizations

Cytoplasm.

Diseases

• Deficiency Of Amp Pyrophorylase
• Neoplasms
• Urolithiasis
• Malignant Neoplasms
• Lesch-nyhan Syndrome
• Kidney Calculi
• Kidney Failure
• Carcinoma
• Gout
• Lithiasis
• Nephrolithiasis
• Cell Transformation, Neoplastic
• Embryonal Carcinoma

• Hereditary Diseases
• Kidney Failure, Chronic
• Malignant Paraganglionic Neoplasm
• Leukemia
• Carcinogenesis
• Inborn Errors Of Metabolism
• Genomic Instability

Pathways

• Methylation
• Mitotic Recombination
• Dna Methylation
• Dna Repair
• Excretion
• Dna Replication
• Mismatch Repair
• Cell Killing
• Cell Cycle
• Demethylation
• Translation
• Transport
• Localization

• Metaphase
• Cell Growth
• Hypersensitivity
• Adenine Salvage
• Gene Conversion
• Regeneration
• Cell Death

PTMs

• Methylation
• Cleavage
• Phosphorylation
• Demethylation
• Deamination
• Formylation

• Decarboxylation
• Ribosylation
• Biotinylation
• Nitration
• Deacetylation
• Acetylation

• Oxidation

Research Areas

• Stem Cell Markers

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/APRT

Boster Bio - Best Uses Of The APRT Marker

Using a protein assay to test cell proliferation and differentiation is a great way to measure the level of a certain protein. Using Boster Bio's APRT Marker can help you find out if your cells are responding to a particular therapy. This protein is also known as APRT, or anti-proliferative factor. The APRT marker is produced from bovine fetal serum. It is compatible with a wide range of mammalian cell types.

Boster Bio's NGF Marker

Boster Bio's NGF Marker allows researchers to assess the effects of nerve growth factor (NGF) on APRT. This polypeptide is produced in the nervous system and regulates the growth and differentiation of sensory and sympathetic neurons. It is located on human chromosome 1p22 and mouse chromosome 3 and has two distinct beta subunits. Mutations in the beta subunit of NGF result in reduced pain perception in individuals with this disorder.

Boster Bio's CD276 Marker

Boster Bio's CD276 APPRT Marker is a highly specific antibody which reacts with human, mouse, and rat cells. The antibody is derived from a mouse immunized with a recombinant protein derived from a region of human CD276. The Boster Bio CD276 APPRT Marker is supplied in PBS containing 0.09% sodium azide and dialysis against PBS. Boster Bio Anti-CD276 antibody was generated from a mouse that was immunized with a recombinant protein derived from the human CD276 gene. For additional information on the Boster Bio CD276 APPRT Marker, you may purchase a blocking peptide for this antibody.

The B7-H3 gene reprogrammes glucose metabolism and has an essential role in cancer cells. The Warburg effect supplies cancer cells with biosynthetic and energy needs, and CD276 targets this gene. Boster Bio's CD276 APRT Marker inhibits tumor cell growth and promotes anti-tumor effects. In this way, the CD276 APRT Marker is highly effective in fighting tumor cells.

In a study involving bladder cancer, researchers found that cancer cells with low levels of CD276 protein were more likely to be malignant. However, this finding is based on preliminary data. Researchers at the University of Chicago Medical Center studied the relationship between CD276 expression and survival. While the exact role of CD276 in cancer remains unclear, it is thought to be an important immune checkpoint molecule that inhibits T cell activation.

Boster Bio's PLG Marker

The PLG Marker is a new type of biomaterial that can encapsulate CpG, GM-CSF, and bacterial antigens. The PLG Marker demonstrates high specificity and displays enhanced inhibitory activity against tumor cells. Its use in immunotherapy is promising for various purposes. Here are some examples of possible applications for this marker. Read on to learn more about the PLG Marker.

Boster Bio's CD326 Marker

The CD326 antigen is a target of immunotherapy for human carcinomas. The CD326 monoclonal antibody is prepared in 10mM PBS and reacts with Human. You can purchase blocking peptide at 1.0 mg/ml to add to the antibody. The cost of blocking peptide varies depending on the length of the immunogen. Boster Bio validates all their antibodies using known positive and negative samples.