ARHGAP17 Antibodies

AND ARHGAP17 ELISA kits, ARHGAP17 Proteins

Many biological assays use antibodies to detect ARHGAP17, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with ARHGAP17 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop ARHGAP17 antibodies...

We validate the specificity of these antibodies to ARHGAP17 by testing them on tissues known to express ARHGAP17 positively and negatively. Browse below to find the ARHGAP17 antibody that suites your experiment. We have 4 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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ARHGAP17 Infographic by Boster Bio

All ARHGAP17 Products

Product

Figures

Specificity

Applications

Price

Anti-RHG17 ARHGAP17 Antibody

6 Q&As

Human, Mouse, Rat

$360
Cat # A07968
100 µl

Anti-ARHGAP17 (T363) Antibody

Human, Mouse, Rat

$405
Cat # A07968T363
100ul

ARHGAP17 (NM_001006634) Human Recombinant Protein

$1249
Cat # PROTQ68EM7
20 µg

ARHGAP17 (NM_001006634) Human Over-expression Lysate

Human

$628
Cat # LS055114
100 µg

ARHGAP17 Overview

Facts about Rho GTPase-activating protein 17.

ARHGAP17 3D structure. Source: alphafold

Rho GTPase-activating protein 17 (ARHGAP17)

Rho GTPase-activating protein involved in the maintenance of tight junction by regulating the activity of CDC42, thereby playing a central role in apical polarity of epithelial cells. Especially acts as a GTPase activator for the CDC42 GTPase by converting it to an inactive GDP-bound state.

The complex formed with AMOT functions by regulating the uptake of polarity proteins at tight junctions, possibly by determining whether tight junction transmembrane proteins are recycled back to the plasma membrane or sent elsewhere. Participates in the Ca(2+)-dependent regulation of exocytosis, maybe by catalyzing GTPase activity of Rho family proteins and by causing the reorganization of the cortical actin filaments.

Gene Information

Human
Gene Name:	ARHGAP17
Uniprot:	Q68EM7
Entrez:	55114

Family

Belongs to:

No superfamily

Alternative Names

DKFZp564A1363; FLJ10308; FLJ13219; FLJ37567; FLJ43368; MGC87805; MST110; MSTP038; MSTP066; MSTP110; NADRIN; neuron-associated developmentally regulated protein; PP367; PP4534; Rho GTPase activating protein 17; rho GTPase-activating protein 17; RhoGAP interacting with CIP4 homologs 1; RhoGAP interacting with CIP4 homologs protein 1; Rho-type GTPase-activating protein 17; RICH-1; RICH1B; RICH1MST066; WBP15

Molecular Weight

Mass (kDA):
95.437 kDA

Genomic Context


Human

Location:	16p12.1
Sequence:	16; NC_000016.10 (24919389..25015601, complement)

Tissue Specificity

Ubiquitously expressed. Expressed at higher level in heart and placenta.

Subcellular Localizations

Membrane; Peripheral membrane protein. Cytoplasm. Cell junction, tight junction. Associates with membranes and concentrates at sites of cell-cell contact.

Diseases

Carcinogenesis
Malignant Neoplasms
Neoplasms
Cell Transformation, Neoplastic
Malignant Neoplasm Of Kidney
Malignant Neoplasm Of Breast
Brain Neoplasms
Malignant Neoplasm Of Lung
Chondrosarcoma
Neurofibromatosis 2
Leukemia

Pheochromocytoma
Lymphoid Leukemia
Malignant Neoplasm Of Pancreas
Chronic Lymphocytic Leukemia
Hyperplasia

Interacting Proteins

AMOT
TRIP10

Pathways

Exocytosis
Localization
Transport
Immune Response
Cell Growth

PTMs

Phosphorylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/ARHGAP17

References

PMID: 11431473 by Richnau N., et al. Rich, a rho GTPase-activating protein domain-containing protein involved in signaling by Cdc42 and Rac1.

PMID: 11285285 by Reczek D., et al. Identification of EPI64, a TBC/rabGAP domain-containing microvillar protein that binds to the first PDZ domain of EBP50 and E3KARP.