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ASXL1 Antibodies
AND ASXL1 ELISA kits, ASXL1 Proteins
Many biological assays use antibodies to detect ASXL1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with ASXL1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop ASXL1 antibodies...
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ASXL1 Infographic by Boster Bio
All ASXL1 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
Flow Cytometry, WB
$370
Cat # A01099
100 μg/vial
Cat # A01099
100 μg/vial
ASXL1 Overview
Facts about Polycomb group protein ASXL1.
Polycomb group protein ASXL1 (ASXL1)
Probable Polycomb group (PcG) protein involved in transcriptional regulation mediated by ligand-bound nuclear hormone receptors, such as retinoic acid receptors (RARs) and peroxisome proliferator-activated receptor gamma (PPARG). Acts as coactivator of RARA and RXRA through association with NCOA1.
Acts as corepressor for PPARG and suppresses its adipocyte differentiation-inducing activity (By similarity). Non-catalytic part of the PR-DUB complex, a complex that specifically mediates deubiquitination of histone H2A monoubiquitinated at'Lys-119' (H2AK119ub1).
Gene Information
| Human | |
|---|---|
| Gene Name: | ASXL1 |
| Uniprot: | Q8IXJ9 |
| Entrez: | 171023 |
Family
| Belongs to: |
|---|
| Asx family |
Alternative Names
additional sex combs like 1 (Drosophila)
Molecular Weight
Mass (kDA):
165.432 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 20q11.21 |
| Sequence: | 20; NC_000020.11 (32358062..32439319) |
Tissue Specificity
Widely expressed at low level. Expressed in heart, brain, skeletal muscle, placenta, pancreas, spleen, prostate, small intestine, colon, peripheral blood, leukocytes, bone marrow and fetal liver. Highly expressed in testes.
Subcellular Localizations
Nucleus.
Diseases
- Leukemia
- Myeloid Leukemia
- Leukemia, Myelocytic, Acute
- Neoplasms
- Dysmyelopoietic Syndromes
- Malignant Neoplasms
- Myeloproliferative Disease
- Thrombocytosis
- Primary Myelofibrosis
- Thrombocythemia, Essential
- Leukemia, Myelomonocytic, Chronic
- Polycythemia Vera
Interacting Proteins
- AKT1
- BAP1
- EED
- ESR1
- EZH2
- Rxra
Pathways
- Pathogenesis
- Methylation
- Dna Methylation
- Histone Modification
- Regulation Of Gene Expression
- Cell Proliferation
- Metaphase
- Cell Cycle
- Chromatin Remodeling
- Localization
PTMs
- Methylation
- Demethylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/ASXL1
bosterbio.com/bosterbio-gene-info-cards/ASXL1
References
PMID: 12657473 by Fisher C.L., et al. A human homolog of Additional sex combs, additional sex combs-like 1, maps to chromosome 20q11.
PMID: 16606617 by Cho Y.S., et al. Additional sex comb-like 1 (ASXL1), in cooperation with SRC-1, acts as a ligand-dependent coactivator for retinoic acid receptor.