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- Table of Contents
1 Citations 6 Q&As
Facts about Cysteine protease ATG4A.
Exposure of the glycine at the C-terminus is essential for ATG8 proteins conjugation into phosphatidylethanolamine (PE) and insertion to membranes, which is essential for autophagy. Preferred substrate is GABARAPL2 followed by MAP1LC3A and GABARAP.
| Human | |
|---|---|
| Gene Name: | ATG4A |
| Uniprot: | Q8WYN0 |
| Entrez: | 115201 |

| Belongs to: |
|---|
| peptidase C54 family |

APG4 autophagy 4 homolog A (S. cerevisiae); Apg4a; ATG4 autophagy related 4 homolog A (S. cerevisiae); ATG4A; Atg4al; Autl2; AUT-like 2 cysteine endopeptidase; AUT-like 2, cysteine endopeptidase (S. cerevisiae); Autophagin 2; autophagin-2; cysteine endopeptidase; cysteine protease ATG4A; EC 3.4.22; EC 3.4.22.-; hAPG4A
Mass (kDA):
45.378 kDA

| Human | |
|---|---|
| Location: | Xq22.3 |
| Sequence: | X; NC_000023.11 (108091667..108154671) |
Widely expressed, at a low level, and the highest expression is observed in skeletal muscle and brain. Also detected in fetal liver.
Cytoplasm.





PMID: 12446702 by Marino G., et al. Human autophagins, a family of cysteine proteinases potentially implicated in cell degradation by autophagy.
PMID: 15169837 by Kabeya Y., et al. LC3, GABARAP and GATE16 localize to autophagosomal membrane depending on form-II formation.