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- Table of Contents
1 Citations
Facts about V-type proton ATPase catalytic subunit A.
In aerobic conditions, involved in intracellular iron homeostasis, thus triggering the activity of Fe(2+) prolyl hydroxylase (PHD) enzymes, and resulting in HIF1A hydroxylation and subsequent proteasomal degradation (PubMed:28296633). May play a role in neurite development and synaptic connectivity (PubMed:29668857).
| Human | |
|---|---|
| Gene Name: | ATP6V1A |
| Uniprot: | P38606 |
| Entrez: | 523 |

| Belongs to: |
|---|
| ATPase alpha/beta chains family |

70kD, isoform 1; ATP6A1; ATP6V1A1ATPase, H+ transporting, lysosomal, subunit A1; ATPase, H+ transporting, lysosomal (vacuolar proton pump), alpha polypeptide; ATPase, H+ transporting, lysosomal 70kDa, V1 subunit A; EC 3.6.3; EC 3.6.3.14; H(+)-transporting two-sector ATPase, subunit A; H+-transporting ATPase chain A, vacuolar (VA68 type); HO68; VA68; vacuolar ATP synthase catalytic subunit A, ubiquitous isoform; Vacuolar ATPase isoform VA68; vacuolar proton pump alpha subunit 1; Vacuolar proton pump subunit alpha; V-ATPase 69 kDa subunit 1; V-ATPase 69 kDa subunit; V-ATPase A subunit 1; V-ATPas
Mass (kDA):
68.304 kDA

| Human | |
|---|---|
| Location: | 3q13.31 |
| Sequence: | 3; NC_000003.12 (113747035..113812056) |
High expression in the skin.
Cytoplasm.




PMID: 8463241 by van Hille B., et al. Identification of two subunit A isoforms of the vacuolar H(+)-ATPase in human osteoclastoma.
PMID: 28065471 by Van Damme T., et al. Mutations in ATP6V1E1 or ATP6V1A cause autosomal-recessive cutis laxa.