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- Table of Contents
ATP6V1A Antibodies
AND ATP6V1A ELISA kits, ATP6V1A Proteins
Many biological assays use antibodies to detect ATP6V1A, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with ATP6V1A in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop ATP6V1A antibodies...
Designing a Western blot for ATP6V1A? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the ATP6V1A Western Blot GuideATP6V1A Infographic by Boster Bio
All ATP6V1A Products
Product
Figures
Specificity
Applications
Price
Anti-ATP6V1A Antibody Picoband®
2 Citations
Human, Mouse, Rat
ELISA, Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # A10401-2
100 μg/vial
Cat # A10401-2
100 μg/vial
Human, Monkey, Mouse, Rat
ELISA, Flow Cytometry, IF, ICC, WB
$370
Cat # A10401-1
100 μg/vial
Cat # A10401-1
100 μg/vial
ATP6V1A Overview
Facts about V-type proton ATPase catalytic subunit A.
V-type proton ATPase catalytic subunit A (ATP6V1A)
Catalytic subunit of the peripheral V1 complex of vacuolar ATPase. V-ATPase vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.
In aerobic conditions, involved in intracellular iron homeostasis, thus triggering the activity of Fe(2+) prolyl hydroxylase (PHD) enzymes, and resulting in HIF1A hydroxylation and subsequent proteasomal degradation (PubMed:28296633). May play a role in neurite development and synaptic connectivity (PubMed:29668857).
Gene Information
| Human | |
|---|---|
| Gene Name: | ATP6V1A |
| Uniprot: | P38606 |
| Entrez: | 523 |
Family
| Belongs to: |
|---|
| ATPase alpha/beta chains family |
Alternative Names
70kD, isoform 1; ATP6A1; ATP6V1A1ATPase, H+ transporting, lysosomal, subunit A1; ATPase, H+ transporting, lysosomal (vacuolar proton pump), alpha polypeptide; ATPase, H+ transporting, lysosomal 70kDa, V1 subunit A; EC 3.6.3; EC 3.6.3.14; H(+)-transporting two-sector ATPase, subunit A; H+-transporting ATPase chain A, vacuolar (VA68 type); HO68; VA68; vacuolar ATP synthase catalytic subunit A, ubiquitous isoform; Vacuolar ATPase isoform VA68; vacuolar proton pump alpha subunit 1; Vacuolar proton pump subunit alpha; V-ATPase 69 kDa subunit 1; V-ATPase 69 kDa subunit; V-ATPase A subunit 1; V-ATPas
Molecular Weight
Mass (kDA):
68.304 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 3q13.31 |
| Sequence: | 3; NC_000003.12 (113747035..113812056) |
Tissue Specificity
High expression in the skin.
Subcellular Localizations
Cytoplasm.
Diseases
- Growth Retardation
- Mucinous Adenocarcinoma
- Ischemia
- Transient Ischemic Attack
- Brain Injuries
Pathways
- Secretion
- Transport
- Proton Transport
- Excretion
- Acid Secretion
- Bone Remodeling
- Regulation Of Bone Remodeling
PTMs
- Acetylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/ATP6V1A
bosterbio.com/bosterbio-gene-info-cards/ATP6V1A
References
PMID: 8463241 by van Hille B., et al. Identification of two subunit A isoforms of the vacuolar H(+)-ATPase in human osteoclastoma.
PMID: 28065471 by Van Damme T., et al. Mutations in ATP6V1E1 or ATP6V1A cause autosomal-recessive cutis laxa.