Aurora kinase A (AURKA)

Mitotic serine/threonine kinase that leads to the regulation of cell cycle progression. Associates with the centrosome and the spindle microtubules during mitosis and plays a critical role in various mitotic events such as the establishment of mitotic spindle, centrosome duplication, centrosome separation in addition to maturation, chromosomal alignment, spindle assembly checkpoint, and cytokinesis.

Required for initial activation of CDK1 in centrosomes. Phosphorylates numerous target proteins, such as ARHGEF2, BORA, BRCA1, CDC25B, DLGP5, HDAC6, KIF2A, LATS2, NDEL1, PARD3, PPP1R2, PLK1, RASSF1, TACC3, p53/TP53 and TPX2.