CDKL5 Antibodies

AND CDKL5 ELISA kits, CDKL5 Proteins

Many biological assays use antibodies to detect CDKL5, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with CDKL5 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop CDKL5 antibodies...

We validate the specificity of these antibodies to CDKL5 by testing them on tissues known to express CDKL5 positively and negatively. Browse below to find the CDKL5 antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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CDKL5 Infographic by Boster Bio

All CDKL5 Products

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Specificity

Applications

Price

Anti-CDKL5 Antibody

Western blot (WB) analysis of CDKL5 polyclonal antibody at 1:500 dilution
Lane1:HEK293Twhole cell lysate
Lane2:Raw264

Human, Mouse, Rat

$405
Cat # A01814
100ul

CDKL5 (NM_001037343) Human Over-expression Lysate

Human

$960
Cat # LS006792
20 µg, 100 µg

CDKL5 Overview

Facts about Cyclin-dependent kinase-like 5.

CDKL5 3D structure. Source: alphafold

Cyclin-dependent kinase-like 5 (CDKL5)

Mediates phosphorylation of MECP2 (PubMed:15917271, PubMed:16935860).
May regulate ciliogenesis (PubMed:29420175).

Gene Information

Human
Gene Name:	CDKL5
Uniprot:	O76039
Entrez:	6792

Family

Belongs to:

protein kinase superfamily

Alternative Names

cyclin-dependent kinase-like 5; serine/threonine kinase 9; serine/threonine-protein kinase 9

Molecular Weight

Mass (kDA):
115.538 kDA

Genomic Context


Human

Location:	Xp22.13
Sequence:	X; NC_000023.11 (18425605..18653629)

Tissue Specificity

Expressed in brain, lung, kidney, prostate, ovary, placenta, pancreas and testis.

Subcellular Localizations

Nucleus. Cytoplasm, cytoskeleton, cilium basal body. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.

Diseases

Rett Syndrome
Epilepsy
Infantile Spasms
Spasm
Encephalopathies
Muscle Hypotonia
Intractable Epilepsy
Developmental Delay (disorder)
Severe Mental Retardation
Microcephaly
Autistic Disorder

Epilepsies, Myoclonic
Developmental Disabilities
X-linked Infantile Spasm Syndrome
Tonic Convulsion
Nervousness

Pathways

Pathogenesis
Localization
Brain Development
Methylation
Forebrain Development
Neurogenesis
Myelination
Translation
Cell Cycle
Drug Resistance
Transport
Cell Adhesion
Pyruvate Oxidation

Hypersensitivity
Nuclear Export
Reflex
Response To Cocaine
Proprioception
Chromatin Remodeling
Cell Proliferation

PTMs

Phosphorylation

Methylation

Oxidation

Research Areas

Protein Kinase

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/CDKL5

References

PMID: 9721213 by Montini E., et al. Identification and characterization of a novel serine-threonine kinase gene from the Xp22 region.

PMID: 12736870 by Kalscheuer V.M., et al. Disruption of the serine/threonine kinase 9 gene causes severe X- linked infantile spasms and mental retardation.