Vasopressin V1a receptor Antibodies

Vasopressin V1a receptor (AVPR1A)

Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl- inositol-calcium second messenger system.

Has been involved in social behaviors, including affiliation and attachment. .

Gene Information

Human
Gene Name:	AVPR1A
Uniprot:	P37288
Entrez:	552

Family

Belongs to:
G-protein coupled receptor 1 family

Alternative Names

Antidiuretic hormone receptor 1a; arginine vasopressin receptor 1A; AVPR V1a; AVPR1; AVPR1A; SCCL vasopressin subtype 1a receptor; V1a Vasopressin R; V1a vasopressin receptor; V1a VasopressinR; V1aR; V1-vascular vasopressin receptor AVPR1A; Vascular/hepatic-type arginine vasopressin receptor; vasopressin V1a receptor

Molecular Weight

Mass (kDA):
46.8 kDA

Genomic Context

Human
Location:	12q14.2
Sequence:	12; NC_000012.12 (63142759..63151201, complement)

Subcellular Localizations

Cell membrane; Multi-pass membrane protein.

Diseases

• Autistic Disorder
• Autism Spectrum Disorders
• Anxiety Disorders
• Dysequilibrium Syndrome
• Pituitary Diseases
• Stress, Psychological
• Septic Shock
• Malnutrition
• Eating Disorders
• Substance-related Disorders
• Variable Number Tandem Repeat
• Bipolar Disorder

• Schizophrenia
• Hypertensive Disease
• Abnormal Behavior
• Essential Hypertension
• Social Phobia
• Neoplasms

Interacting Proteins

• ACKR3
• CXCR4

Pathways

• Social Behavior
• Mating
• Cognition
• Secretion
• Response To Stress
• Prepulse Inhibition
• Localization
• Startle Response
• Transport
• Ion Transport
• Associative Learning
• Eating Behavior

• Oxytocin Secretion
• Ovulation
• Proestrus
• Maternal Behavior
• Mrna Transcription
• Translation
• Histone Acetylation

PTMs

• Disulfide bond
• Glycoprotein

• Lipoprotein
• Palmitate

• Phosphoprotein

Research Areas

• GPCR

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/AVPR1A

Best Uses Of The AVPR1A Marker From Boster Bio

AVPR1A, an antigen linked with the apolipoprotein E is a popular target for drug discovery and gene therapy. Boster utilizes both positive and negative samples to confirm antibodies. This guarantees high specificity and affinity. Boster rewards and credits scientists around the world who have a look at their products prior to going for sale to celebrate their success.

Anti-AVPR1A Monoclonal antibody

This Anti-AVPR1A monoclone from Boster Bio has been tested in WB applications. It is formulated in PBS with 0.09 percent sodium azide. It was prepared through Euglobin precipitation followed by dialysis on PBS. The AVPR1A gene can be found on all human cells. This monoclonal antibody is created through vaccination of mice with the synthetic peptide. You can purchase a blocking peptide for an additional fee or to be used in social behavior research.

The Boster Anti-AVPR1A monoclone has been verified in flow cytometry IP, IF, and ICC. It was also tested on mouse, human and rat cell lines. It reacts to AVPR1A protein in all the tested applications. It is also available as a variety conjugates, such as goat anti-rabbit polyclonal, polyclonal, for rabbits, and polyclonal to goats.

AVPR1A is a protein present in the kidney and in other blood. Monoclonal antibodies are derived from plasma B cells that have been fused myeloma cell lines. They have the same properties and can be used in a variety of applications with no issues of consistency. The boster bio antibody is a specific monoclonal antibody that will bind to AVPR1A.

Validation

Autism and other developmental disorders are associated with the AVPR1A gene. Genetic variants in this gene have been linked to these disorders. We confirmed the AVPR1A genetic by testing for connections between specific SNPs with severity of autism. We looked into the connection between the subphenotype AVPR1A, which is similar to autism, and Insistence on a Sameness, also known as social withdrawal.

AVPR1A microsatellites (RS1, RS3, RS8 and RS8) were examined to determine if they were associated with ASD or subphenotypes. The RS3-repeat mutation was associated with PBS in both genders. However, no correlation was observed between the other AVPR1A mutations. In the end, we are confident about the accuracy of this marker.

The RS3 repeat of AVPR1A has been found to be associated with characteristics that reflect couple-bonding in males. Despite this association, AVPR1A Polymorphism isn't a reliable predictor of couple-bonding behaviour. This suggests that it could have a slight, but significant effect on the behaviors. We cannot exclude its significance to group behavior from this study.

To examine the relationship between autism and the AVPR1A genetics, the AVPR1A gene was studied in Israeli families. In this study, a single SNP was identified to be associated with autism, and it was the microsatellite rs11174815. The researchers suggest that this minor allele frequency may be the reason behind the lack of association with autism in the Irish sample population.

Despite these limitations AVPR1A gene mutations have been linked to autism and other social behaviours. Additionally, a genetic variation in RS1-310 may affect the regulation of AVPR1A gene expression. Further research should study the polymorphisms within different brain regions and cell types to determine their significance in the neurobiology behind autism and social behavior.

Applications

Recent studies have revealed that the AVPR1A marker can be related to reciprocity in gambling as well as in a variety of other situations. People with shorter AVPR1A repeat lengths gave money to opponents who believed in them. Although this is a remarkably significant correlation, it cannot be fully explained by the idea that AVPR1A is associated with a higher AVP. It could be that AVP is not specifically responsible for regulating the anxiety associated with exploitation or loss of money. In this case it could be that the gene controls anxiety associated with exploitation and loss of money, not just generalized anxiety.

G-protein-coupled receptor AVPR1A connects to arginine vasopressin. Its activity is mediated by G proteins that activate the phosphatidylinositol-calcium second messenger system. Its function in physiological processes involves the control of cell contraction, platelet aggregation and release of coagulation factors. It has also been linked with social behavior, however its precise function is being determined.

Inoue-Murayama et al. also examined the association with microsatellite polymorphisms within the AVPR1A intron and socialization. They found that those who had a shorter AVPR1a marker were more socially active. However, the results were not similar across social species, this suggests that the relationship is relevant to human behavior.

Furthermore, in a separate study, the AVPR1A gene expression in the placental vessels of pre-eclampty was significantly increased in patients with pre-eclampsia. AVPR1A gene methylation and AVPR1A gene expression were inversely connected in the PE group. The reduction in AVP sensitivity was also associated with an increase in AVPR1A gene methylation. These results support further investigation into the AVPR1A genes.

Gene infographics

The gene AVPR1A has been linked to a variety of psychological disorders such as anxiety, depression, and impulsivity. While this association is mostly dependent on phenotypic evidence studies have also suggested that this gene could be linked with other mental disorders too. This article will discuss potential connections and informationgraphics about the gene for AVPR1A. This gene is home to a variety of interesting and informative infographics.

The gene AVPR1a is related to human social behavior. A shorter version of AVPR1a might increase the likelihood for people to give money back to trusted adversaries. Other people with this gene are less likely to trust other people and have a more aggressive tendencies. It plays a significant role in trust and reciprocal behavior. It may even influence our emotional or reaction to money.

Childhood onset mood disorders were connected to the AVPR1B gene. Statistically significant results were obtained by using single-marker and haplotype analysis. Multiple-marker analyses were adjusted for multiple genotypes using permutation calculations. This association could be gender-specific. This study only included female patients and controls. This is fantastic news for people suffering from depression and other mental disorders.

Microsatellite polymorphisms that occur in the AVPR1A promoter region have been extensively studied. Inoue-Murayama et al. The length of the intron repetition was associated with social behavior in common marmosets. These results indicate that this marker is associated with social behavior in non-human primates. Therefore, genetic testing is necessary to determine the short or long allele of AVPR1A.