Zinc-alpha-2-glycoprotein Antibodies

Zinc-alpha-2-glycoprotein (AZGP1)

Stimulates lipid degradation in adipocytes and causes the fat losses associated with some advanced cancers. May bind polyunsaturated fatty acids.

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Gene Information

Human
Gene Name:	AZGP1
Uniprot:	P25311
Entrez:	563

Family

Belongs to:
MHC class I family

Alternative Names

alpha-2-glycoprotein 1, zinc; alpha-2-glycoprotein 1, zinc-binding; AZGP1; ZA2G; ZAG; ZAGzn-alpha-2-GP; zinc; zinc-alpha-2-glycoprotein; zn-alpha-2-glycoprotein; ZNGP1

Molecular Weight

Mass (kDA):
34.259 kDA

Genomic Context

Human
Location:	7q22.1
Sequence:	7; NC_000007.14 (99966730..99976031, complement)

Tissue Specificity

Blood plasma, seminal plasma, urine, saliva, sweat, epithelial cells of various human glands, liver.

Subcellular Localizations

Secreted.

Diseases

• Malignant Neoplasms
• Neoplasms
• Carcinoma
• Obesity
• Prostatic Neoplasms
• Malignant Neoplasm Of Prostate
• Diabetes Mellitus
• Cachexia
• Adenocarcinoma
• Mammary Neoplasms
• Diabetes Mellitus, Non-insulin-dependent
• Neoplasm Metastasis
• Ductal Breast Carcinoma

• Insulin Resistance
• Malignant Neoplasm Of Breast
• Diabetic Nephropathy
• Neoplasm Recurrence, Local
• Malignant Paraganglionic Neoplasm
• Malignant Neoplasm Of Pancreas
• Neoplasm Invasiveness

Interacting Proteins

• PRNP

Pathways

• Transport
• Fertilization
• Localization
• Pathogenesis
• Histone Deacetylation
• Flight
• Secretion
• Cell Adhesion
• Transposition
• Immune Response
• Glomerular Filtration
• Methylation

• Sperm Motility
• Histone Acetylation
• Cell Growth
• Cell Communication
• Mating
• Transdifferentiation
• Chromatin Remodeling

PTMs

• Phosphorylation
• Cleavage
• Deacetylation

• Glycosylation
• Acetylation
• Methylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/AZGP1

Best Uses Of The AZGP1 Marker

This article will discuss Steven Boster, AZGP1’s alternate splice forms and its C-terminal amin acid substitution. You will also find the latest research about Boster's work. Boster also provides valuable resources for biomedical research. We will talk about his life and work. After all, it's not just a story about his work.

Information about AZGP1

Researchers recently discovered that AZGP1 in brains can reduce the severity or duration of seizures. Researchers also found that AZGP1 overexpression inhibits the activity the mammalian target-of-rapamycin pathway, or mTOR. mTOR regulates various cellular processes, and AZGP1 may be a promising therapeutic target.

The AZGP1 gene encodes a protein called zinc-alpha-2-glycoprotein. It is part of the MHC class I family and is present in human body fluids and is believed to play an important role in the regulation of weight and in the regulation of melanin production. Scientists believe it may play a key role in weight regulation.

The researchers looked at the rat's hippocampus. They injected AAV-GFP into a group of rats. After three weeks, AZGP1 mRNA level and ZAG protein levels were higher. After nine week, AZGP1 expression remained steady in the control. This shows that the AZGP1 genes plays an important part in the development of brain diseases, including Alzheimer's.

Information about AZGP1’s amino acid substitution at the C-terminal

AZGP1 - A type of zinc-containing, glycoprotein, is found in seminal Plasma, urine and sweat, saliva, liver and epithelial cell of various human organs. It is believed to regulate body fat and promote lipid loss in adipocytes. One MHC class I region is present in mature human AZGP1. The C-terminal amino acid substitutions in the protein are responsible for the zinc-containing domain.