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Antizyme inhibitor 2 Antibodies
AND AZIN2 ELISA kits, Antizyme inhibitor 2 Proteins
Many biological assays use antibodies to detect Antizyme inhibitor 2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Antizyme inhibitor 2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Antizyme inhibitor 2 antibodies...
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AZIN2 Infographic by Boster Bio
All AZIN2 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
IHC, WB
$370
Cat # RP1112
100 μg/vial
Cat # RP1112
100 μg/vial
Human, Mouse, Rat
ELISA, Flow Cytometry, IHC, WB
$370
Cat # A07836
100 μg/vial
Cat # A07836
100 μg/vial
AZIN2 Overview
Facts about Antizyme inhibitor 2.
Antizyme inhibitor 2 (AZIN2)
Antizyme inhibitor (AZI) protein that positively regulates ornithine decarboxylase (ODC) activity and polyamine uptake. AZI is an enzymatically inactive ODC homolog that counteracts the negative effect of ODC antizymes (AZs) OAZ1, OAZ2 and OAZ3 on ODC activity by competing with ODC for antizyme- binding (PubMed:17900240).
Inhibits antizyme-dependent ODC degradation and releases ODC monomers from their inactive complex with antizymes, leading to formation of the catalytically active ODC homodimer and restoring polyamine production (PubMed:17900240). Participates in the morphological integrity of the trans-Golgi network (TGN) and acts as a regulator of intracellular secretory vesicle trafficking (PubMed:20188728).
Gene Information
| Human | |
|---|---|
| Gene Name: | AZIN2 |
| Uniprot: | Q96A70 |
| Entrez: | 113451 |
Family
| Belongs to: |
|---|
| Orn/Lys/Arg decarboxylase class-II family |
Alternative Names
Antizyme inhibitor 2
Molecular Weight
Mass (kDA):
49.98 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 1p35.1 |
| Sequence: | 1; NC_000001.11 (33081152..33162288) |
Tissue Specificity
Expressed in the neocortex, thalamus, hippocampus, cerebellum, medulla oblongata, gray and white matter. Expressed in neurons, oligodendrocytes, basket, Purkinje and pyramidal cells. Expressed in spermatocytes and Leydig cells of the testis. Expressed in luteal theca cells lining corpus luteum cysts and in hilus cells of the ovary. Expressed in primary and neoplastic mast cells (MC) (at protein level). Highly expressed in brain. Also expressed in testis.
Subcellular Localizations
Nucleus. Cytoplasm. Cytoplasm, perinuclear region. Membrane. Cytoplasmic vesicle. Endoplasmic reticulum-Golgi intermediate compartment. Golgi apparatus, cis-Golgi network. Golgi apparatus, trans-Golgi network. Cytoplasmic granule. Cell projection, axon. Cell projection, dendrite. Perikaryon. Colocalizes with KDEL receptors in ER-Golgi intermediate compartment (ERGIC). Translocates from the ERGIC structure to the cytoplasm in an antizyme-dependent manner. Localizes with vesicle-associated membrane protein VAMP8 in the vicinity of the plasma membrane within serotonin-containing secretory granule
Interacting Proteins
- OAZ3
PTMs
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/AZIN2
bosterbio.com/bosterbio-gene-info-cards/AZIN2
References
PMID: 11587527 by Pitkaenen L.T., et al. Expression of a novel human ornithine decarboxylase-like protein in the central nervous system and testes.
PMID: 14738999 by Zhu M.-Y., et al. Expression of human arginine decarboxylase, the biosynthetic enzyme for agmatine.