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BAZ1B Antibodies
AND BAZ1B ELISA kits, BAZ1B Proteins
Many biological assays use antibodies to detect BAZ1B, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with BAZ1B in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop BAZ1B antibodies...
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BAZ1B Infographic by Boster Bio
All BAZ1B Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
WB
$523
Cat # M04438
100 µl
Cat # M04438
100 µl
Human, Mouse, Rat
Flow Cytometry, WB
$370
Cat # M04438-1
100 μl/vial
Cat # M04438-1
100 μl/vial
BAZ1B Overview
Facts about Tyrosine-protein kinase BAZ1B.
Tyrosine-protein kinase BAZ1B (BAZ1B)
Atypical tyrosine-protein kinase that plays a central role in chromatin remodeling and acts as a transcription regulator. Involved in DNA damage response by phosphorylating 'Tyr-142' of histone H2AX (H2AXY142ph).
H2AXY142ph plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress. Essential part of the WICH complicated, a chromatin remodeling complex that mobilizes nucleosomes and reconfigures irregular chromatin into a regular nucleosomal array structure.
Gene Information
| Human | |
|---|---|
| Gene Name: | BAZ1B |
| Uniprot: | Q9UIG0 |
| Entrez: | 9031 |
Family
| Belongs to: |
|---|
| WAL family |
Alternative Names
bromodomain adjacent to zinc finger domain, 1B; williams-Beuren syndrome chromosomal region 10 protein
Molecular Weight
Mass (kDA):
170.903 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 7q11.23 |
| Sequence: | 7; NC_000007.14 (73440406..73522293, complement) |
Tissue Specificity
Ubiquitously expressed with high levels of expression in heart, brain, placenta, skeletal muscle and ovary.
Subcellular Localizations
Nucleus. Accumulates in pericentromeric heterochromatin during replication. Targeted to replication foci throughout S phase via its association with PCNA.
Diseases
- Williams Syndrome
- Neoplasms
- Haploinsufficiency
- Cardiovascular Abnormalities
- Carcinogenesis
- Malignant Neoplasms
- Radiation Injury
- Adenoma
- Stenosis
- Neoplasms, Radiation-induced
- Multiple Organ Failure
- Colonic Neoplasms
Interacting Proteins
- SMARCA5
Pathways
- Chromatin Remodeling
- Atp-dependent Chromatin Remodeling
- Dna Repair
- Dna Replication
- Cell Death
- Histone Deacetylation
- Gene Silencing
- Nucleosome Positioning
- Dna Methylation
- Histone Modification
- Localization
- Methylation
PTMs
- Phosphorylation
- Acetylation
- Ubiquitination
- Biotinylation
Research Areas
- Transcription Factors and Regulators
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/BAZ1B
bosterbio.com/bosterbio-gene-info-cards/BAZ1B
References
PMID: 9858827 by Peoples R.J., et al. Identification of the WBSCR9 gene, encoding a novel transcriptional regulator, in the Williams-Beuren syndrome deletion at 7q11.23.
PMID: 9828126 by Lu X., et al. A novel human gene, WSTF, is deleted in Williams Syndrome.