- Table of Content
Receptor for CCL19 and chemerin/RARRES2.Does not seem to be a signaling receptor, but may have a role in modulating chemokine-triggered immune responses by catching and internalizing CCL19 or by presenting RARRES2 ligand to CMKLR1, a functional signaling receptors.
Plays a crucial role for the development of Th2 responses. .
|G-protein coupled receptor 1 family|
|Sequence:||3; NC_000003.12 (46407166..46409523)|
Expressed abundantly in immunal tissues such as spleen, fetal liver, lymph node and bone marrow. Strong expression also in lung and heart. Expressed in almost all hematopoietic cells including monocytes, macrophages, PMNs, T- cells (both CD4+ and CD8+), monocyte-derived iDCs, NK cells, and CD34+ progenitor cells. B-cells expressed isoform 1 but not isoform 2. Up-regulated on synovial neutrophils of rheumatoid arthritis patients.
Cell membrane; Multi-pass membrane protein.