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- Table of Contents
Facts about Bcl-2-like protein 2.
Mediates survival of postmitotic Sertoli cells by suppressing death-promoting activity of BAX. .
| Human | |
|---|---|
| Gene Name: | BCL2L2 |
| Uniprot: | Q92843 |
| Entrez: | 599 |

| Belongs to: |
|---|
| Bcl-2 family |

Apoptosis regulator Bcl-W; BCL2L2; Bcl2-L-2; BCL2-like 2; Bclw; Bcl-w; BCLWbcl-2-like protein 2; KIAA0271BCL2-L-2
Mass (kDA):
20.746 kDA

| Human | |
|---|---|
| Location: | 14q11.2 |
| Sequence: | 14; NC_000014.9 (23306833..23311759) |
Expressed (at protein level) in a wide range of tissues with highest levels in brain, spinal cord, testis, pancreas, heart, spleen and mammary glands. Moderate levels found in thymus, ovary and small intestine. Not detected in salivary gland, muscle or liver. Also expressed in cell lines of myeloid, fibroblast and epithelial origin. Not detected in most lymphoid cell lines.
Mitochondrion membrane; Peripheral membrane protein. Loosely associated with the mitochondrial membrane in healthy cells. During apoptosis, tightly bound to the membrane.






PMID: 8761287 by Gibson L., et al. Bcl-w, a novel member of the Bcl-2 family, promotes cell survival.
PMID: 11423909 by O'Reilly L.A., et al. Tissue expression and subcellular localization of the pro-survival molecule Bcl-w.
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