Chromobox protein homolog 5 (Cbx5)

Component of heterochromatin that recognizes and binds histone H3 tails methylated at'Lys-9' (H3K9me), leading to epigenetic repression. In contrast, it's excluded from chromatin when'Tyr-41' of histone H3 is phosphorylated (H3Y41ph).

Can interact with lamin-B receptor (LBR). This interaction can lead to the institution of the heterochromatin with the inner nuclear membrane.