Product Info Summary
SKU: | A02780S92 |
---|---|
Size: | 100ul |
Reactive Species: | Human |
Host: | Rabbit |
Application: | ELISA, IHC |
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Product info
Product Name
Anti-Phospho-HP alpha (S92) CBX5 Antibody
SKU/Catalog Number
A02780S92
Size
100ul
Form
Liquid
Description
Boster Bio Anti-Phospho-HP alpha (S92) CBX5 Antibody catalog # A02780S92. Tested in ELISA, IHC applications. This antibody reacts with Human.
Storage & Handling
Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Cite This Product
Anti-Phospho-HP alpha (S92) CBX5 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A02780S92)
Host
Rabbit
Contents
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Clonality
Polyclonal
Isotype
IgG
Immunogen
Synthesized peptide derived from human HP1alpha around the phosphorylation site of S92.
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Reactive Species
A02780S92 is reactive to Cbx5 in Human
Applications
A02780S92 is guaranteed for ELISA, IHC Boster Guarantee
Observed Molecular Weight
Calculated molecular weight
22.186kDa
Background of HP1 alpha
AMP/ATP-binding subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Gamma non-catalytic subunit mediates binding to AMP, ADP and ATP, leading to activate or inhibit AMPK: AMP-binding results in allosteric activation of alpha catalytic subunit (PRKAA1 or PRKAA2) both by inducing phosphorylation and preventing dephosphorylation of catalytic subunits. ADP also stimulates phosphorylation, without stimulating already phosphorylated catalytic subunit. ATP promotes dephosphorylation of catalytic subunit, rendering the AMPK enzyme inactive.
Cheung P.C.F., Biochem. J. 346:659-669(2000).
Lang T.M., Genomics 70:258-263(2000).
Ota T., Nat. Genet. 36:40-45(2004).
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
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Assay dilution & Images
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
IHC 1:100-1:300
ELISA 1:40000
Validation Images & Assay Conditions
Click image to see more details
Figure 1. Immunohistochemistry validation of CBX5 using Anti-Phospho-HP alpha (S92) CBX5 Antibody (A02780S92).
Immunohistochemical analysis of paraffin-embedded Human breast cancer. Antibody was diluted at 1:100 (4°CProtein Target Info & Infographic
Gene/Protein Information For Cbx5 (Source: Uniprot.org, NCBI)
Gene Name
Cbx5
Full Name
Chromobox protein homolog 5
Weight
22.186kDa
Alternative Names
Antigen p25; chromobox homolog 5 (Drosophila HP1 alpha); chromobox homolog 5 (HP1 alpha homolog, Drosophila); chromobox homolog 5; chromobox protein homolog 5; Heterochromatin protein 1 homolog alpha; heterochromatin protein 1-alpha; HP1 alpha homolog; HP1 alpha; HP1; HP1A; HP1-ALPHA; HP1Hs alpha; HP1Hs-alpha Cbx5|2610029O15Rik, C75991, HP, HP1, Hp1a, Hp1alpha|chromobox 5|chromobox protein homolog 5|HP1 alpha|chromobox homolog 5|heterochromatin protein 1 alpha|heterochromatin protein 1 homolog alpha|mHP1(alpha)
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on Cbx5, check out the Cbx5 Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for Cbx5: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-Phospho-HP alpha (S92) CBX5 Antibody (A02780S92)
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No publications found for A02780S92
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