Anti-CBX5 (K69) Antibody

HP1 alpha antibody

Boster Bio Anti-CBX5 (K69) Antibody catalog # A02780-2. Tested in WB,IHC,IF applications. This antibody reacts with Human,Mouse,Rat.

Product Info Summary

SKU: A02780-2
Size: 100ul
Reactive Species: Human, Mouse, Rat
Host: Rabbit
Application: IF, IHC, WB

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Product Name

Anti-CBX5 (K69) Antibody

View all HP1 alpha Antibodies

SKU/Catalog Number

A02780-2

Size

100ul

Form

Liquid

Description

Boster Bio Anti-CBX5 (K69) Antibody catalog # A02780-2. Tested in WB,IHC,IF applications. This antibody reacts with Human,Mouse,Rat.

Storage & Handling

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Cite This Product

Anti-CBX5 (K69) Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A02780-2)

Host

Rabbit

Contents

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Clonality

Polyclonal

Isotype

IgG

Immunogen

Synthesized peptide derived from human Bcl-3

*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.

Reactive Species

A02780-2 is reactive to Cbx5 in Human, Mouse, Rat

Applications

A02780-2 is guaranteed for IF, IHC, WB Boster Guarantee

Observed Molecular Weight

Calculated molecular weight

22.186kDa

Background of HP1 alpha

AMP/ATP-binding subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Gamma non-catalytic subunit mediates binding to AMP, ADP and ATP, leading to activate or inhibit AMPK: AMP-binding results in allosteric activation of alpha catalytic subunit (PRKAA1 or PRKAA2) both by inducing phosphorylation and preventing dephosphorylation of catalytic subunits. ADP also stimulates phosphorylation, without stimulating already phosphorylated catalytic subunit. ATP promotes dephosphorylation of catalytic subunit, rendering the AMPK enzyme inactive.

Cheung P.C.F., Biochem. J. 346:659-669(2000).
Lang T.M., Genomics 70:258-263(2000).
Ota T., Nat. Genet. 36:40-45(2004).

Antibody Validation

Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.

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Assay Dilutions Recommendation

The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.

WB: 1:500-1:1000
IHC: 1:50-1:200
IF: 1:50-1:200

Validation Images & Assay Conditions

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Gene/Protein Information For Cbx5 (Source: Uniprot.org, NCBI)

Gene Name

Cbx5

Full Name

Chromobox protein homolog 5

Weight

22.186kDa

Alternative Names

Antigen p25; chromobox homolog 5 (Drosophila HP1 alpha); chromobox homolog 5 (HP1 alpha homolog, Drosophila); chromobox homolog 5; chromobox protein homolog 5; Heterochromatin protein 1 homolog alpha; heterochromatin protein 1-alpha; HP1 alpha homolog; HP1 alpha; HP1; HP1A; HP1-ALPHA; HP1Hs alpha; HP1Hs-alpha Cbx5|2610029O15Rik, C75991, HP, HP1, Hp1a, Hp1alpha|chromobox 5|chromobox protein homolog 5|HP1 alpha|chromobox homolog 5|heterochromatin protein 1 alpha|heterochromatin protein 1 homolog alpha|mHP1(alpha)

*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".

For more info on Cbx5, check out the Cbx5 Infographic

Cbx5 infographic

We have 30,000+ of these available, one for each gene! Check them out.

In this infographic, you will see the following information for Cbx5: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].

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Order DetailsPrice
A02780-2-100ul

100ul

$405

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