Hydroxycarboxylic acid receptor 3 (HCAR3)

Receptor for 3-OH-octanoid acid mediates a negative feedback regulation of adipocyte lipolysis to counteract prolipolytic affects under conditions of physiological or pathological increases in beta-oxidation rates. Acts as a low affinity receptor for nicotinic acid.

This pharmacological effect requires nicotinic acid doses which are much higher than those supplied by a standard diet. .