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- Table of Contents
G1/S-specific cyclin-D2 Antibodies
AND CCND2 ELISA kits, G1/S-specific cyclin-D2 Proteins
Many biological assays use antibodies to detect G1/S-specific cyclin-D2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with G1/S-specific cyclin-D2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop G1/S-specific cyclin-D2 antibodies...
Designing a Western blot for G1/S-specific cyclin-D2? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the CCND2 Western Blot GuideCCND2 Infographic by Boster Bio
All CCND2 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
ELISA
$480
Cat # EKC1154
1 kit, containing one 96-well plate and all necessary reagents
Cat # EKC1154
1 kit, containing one 96-well plate and all necessary reagents
CCND2 Overview
Facts about G1/S-specific cyclin-D2.
G1/S-specific cyclin-D2 (CCND2)
Regulatory component of the cyclin D2-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complicated and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase.
Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals.
Gene Information
| Human | |
|---|---|
| Gene Name: | CCND2 |
| Uniprot: | P30279 |
| Entrez: | 894 |
Family
| Belongs to: |
|---|
| cyclin family |
Alternative Names
CCND2; Cyclin D2; G1/S-specific cyclin D2; G1/S-specific cyclin-D2; KIAK0002; MGC102758; Vin1
Molecular Weight
Mass (kDA):
33.067 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 12p13.32 |
| Sequence: | 12; NC_000012.12 (4273762..4305353) |
Subcellular Localizations
Nucleus. Cytoplasm. Membrane. Cyclin D-CDK4 complexes accumulate at the nuclear membrane and are then translocated into the nucleus through interaction with KIP/CIP family members.; [Isoform 2]: Cytoplasm.
Diseases
- Neoplasms
- Malignant Neoplasms
- Carcinoma
- Retinoblastoma
- Cell Transformation, Neoplastic
- Leukemia
- Lymphoma
- Malignant Paraganglionic Neoplasm
- Malignant Neoplasm Of Breast
- Mammary Neoplasms
- Multiple Myeloma
- Carcinogenesis
- B-cell Lymphomas
Interacting Proteins
- CDK4
- CDK5
- CDKN1A
- CDKN1B
Pathways
- Cell Cycle
- Cell Proliferation
- Methylation
- S Phase
- G1 Phase
- Cell Growth
- Cell Cycle Arrest
- Pathogenesis
- Cell Death
- Cell Division
- Localization
- Cell Differentiation
- Dna Methylation
PTMs
- Phosphorylation
- Methylation
- Cleavage
- Demethylation
- Dephosphorylation
Research Areas
- Cell Cycle and Replication
- Core ESC-Like Genes
- Ovarian Carcinoma Cell Markers
- Stem Cell Markers
- Wnt Signaling Pathway
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/CCND2
bosterbio.com/bosterbio-gene-info-cards/CCND2
References
PMID: 1386336 by Xiong Y., et al. Molecular cloning and chromosomal mapping of CCND genes encoding human D-type cyclins.
PMID: 8455931 by Palmero I., et al. Cyclins D1 and D2 are differentially expressed in human B-lymphoid cell lines.
2 Publications of Boster G1/S-specific cyclin-D2 Antibodies & ELISA Kits
- PubMed ID: 27855694, CD274 promotes cell cycle entry of leukemia-initiating cells through JNK/Cyclin ...
- PubMed ID: 24853807, Sun L, Carr Al, Li P, Lee J, Mcgregor M, Li L. Biochem Biophys Res Commun. 2014 ...
*More publications can be found for each product on its corresponding product page