- Table of Content
Can function as a chemoattractant homing receptor on circulating memory lymphocytes and as a coreceptor for some main HIV-2 isolates. In the CNS, could mediate hippocampal-neuron survival.
|G-protein coupled receptor 1 family|
|Sequence:||3; NC_000003.12 (32951555..32956349)|
Predominantly expressed in the thymus, in peripheral blood leukocytes, including T-cells, mostly CD4+ cells, and basophils, and in platelets; at lower levels, in the spleen and in monocytes. Detected also in macrophages, IL-2-activated natural killer cells and skin-homing memory T-cells, mostly the ones expressing the cutaneous lymphocyte antigen (CLA). Expressed in brain microvascular and coronary artery endothelial cells.
Cell membrane; Multi-pass membrane protein.
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