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- Table of Contents
CCR4 Antibodies
AND CCR4 ELISA kits, CCR4 Proteins
Many biological assays use antibodies to detect CCR4, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with CCR4 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop CCR4 antibodies...
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CCR4 Infographic by Boster Bio
All CCR4 Products
Product
Figures
Specificity
Applications
Price
Mouse, Rat
WB
$370
Cat # PA1517
100 μg/vial
Cat # PA1517
100 μg/vial
Human, Mouse, Rat
ELISA, Flow Cytometry, WB
$370
Cat # A00755-4
100 µg/vial
Cat # A00755-4
100 µg/vial
Human
ELISA, Flow Cytometry, Functional Assay, Kinetics
$486
Cat # M00755
100 μg
Cat # M00755
100 μg
CCR4 Overview
Facts about C-C chemokine receptor type 4.
C-C chemokine receptor type 4 (CCR4)
High affinity receptor for the C-C type chemokines CCL17/TARC, CCL22/MDC and CKLF isoform 1/CKLF1. The activity of this receptor is mediated by G(I) proteins which activate a phosphatidylinositol-calcium second messenger system.
Can function as a chemoattractant homing receptor on circulating memory lymphocytes and as a coreceptor for some main HIV-2 isolates. In the CNS, could mediate hippocampal-neuron survival.
Gene Information
| Human | |
|---|---|
| Gene Name: | CCR4 |
| Uniprot: | P51679 |
| Entrez: | 1233 |
Family
| Belongs to: |
|---|
| G-protein coupled receptor 1 family |
Alternative Names
C-C chemokine receptor type 4; C-C CKR-4; CC-CKR-4HGCN:14099; CCR4; CCR-4; CD194 antigen; CD194; chemokine (C-C motif) receptor 4; chemokine (C-C) receptor 4; ChemR13; CKR4MGC88293; CMKBR4k5-5; K5-5
Molecular Weight
Mass (kDA):
41.403 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 3p22.3 |
| Sequence: | 3; NC_000003.12 (32951555..32956349) |
Tissue Specificity
Predominantly expressed in the thymus, in peripheral blood leukocytes, including T-cells, mostly CD4+ cells, and basophils, and in platelets; at lower levels, in the spleen and in monocytes. Detected also in macrophages, IL-2-activated natural killer cells and skin-homing memory T-cells, mostly the ones expressing the cutaneous lymphocyte antigen (CLA). Expressed in brain microvascular and coronary artery endothelial cells.
Subcellular Localizations
Cell membrane; Multi-pass membrane protein.
Diseases
- Inflammation
- Cholangiocarcinoma
- Neoplasms
- Dermatitis
- Asthma
- Malignant Neoplasms
- Lymphoma
- Dermatitis, Atopic
- Hiv Infections
- Autoimmune Reaction
- Adult T-cell Lymphoma/leukemia
- Tissue Adhesions
- Allergy
Interacting Proteins
- CCL17
Pathways
- Pathogenesis
- Chemotaxis
- Immune Response
- Secretion
- Cytokine Production
- Cell Migration
- Localization
- Translation
- Hypersensitivity
- Cell Proliferation
- Cell Activation
- Chemokine Production
- T Cell Activation
PTMs
- Phosphorylation
- Cleavage
- Methylation
- Ubiquitination
Research Areas
- Chemokines and Cytokines
- Cytokine Research
- GPCR
- Immunology
- Innate Immunity
- Signal Transduction
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/CCR4
bosterbio.com/bosterbio-gene-info-cards/CCR4
References
PMID: 7642634 by Power C.A., et al. Molecular cloning and functional expression of a novel CC chemokine receptor cDNA from a human basophilic cell line.
PMID: 11196669 by Kato H., et al. New variations of human CC-chemokine receptors CCR3 and CCR4.
1 Publications of Boster CCR4 Antibodies & ELISA Kits
- PubMed ID: 24416340, Zhao C, Bu X, Wang W, Ma T, Ma H. Plos One. 2014 Jan 8;9(1):E85058. Doi: 10.1371...
*More publications can be found for each product on its corresponding product page