C-C chemokine receptor type 4 (CCR4)

High affinity receptor for the C-C type chemokines CCL17/TARC, CCL22/MDC and CKLF isoform 1/CKLF1. The activity of this receptor is mediated by G(I) proteins which activate a phosphatidylinositol-calcium second messenger system.

Can function as a chemoattractant homing receptor on circulating memory lymphocytes and as a coreceptor for some main HIV-2 isolates. In the CNS, could mediate hippocampal-neuron survival.