Anti-C-C chemokine receptor type 4 CCR4 Antibody
Rabbit IgG polyclonal antibody for C-C chemokine receptor type 4(CCR4) detection. Tested with WB in Mouse;Rat. Cited in 1 publication(s).
Anti-C-C chemokine receptor type 4 CCR4 Antibody Info At A Glance
|Product Name||Anti-C-C chemokine receptor type 4 CCR4 Antibody
See all Ccr4 primary antibodies, ELISA kits and proteins
|Storage & Handling||At -20°C for one year. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for a longer time.Avoid repeated freezing and thawing.|
|Description||Polyclonal antibody for CCR4 detection. Host: Rabbit.Size: 100μg/vial. Tested applications: WB. Reactive species: Mouse. CCR4 information: Molecular Weight: 41408 MW; Subcellular Localization: Cell membrane; Multi-pass membrane protein; Tissue Specificity: Expressed in the thymus, macrophages and T- and B-cells.|
|Cite This Product||Anti-C-C chemokine receptor type 4 CCR4 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # PA1517)|
|Similar Products From
|Anti-C-C chemokine receptor type 4 CCR4 Antibody may replace the following items: sc 368501|sc 67660|sc 67658|sc 67653|sc 67659|sc 67657|sc 67655|sc 398006.|
*This antibody is predicted to react with the above species based on antigen sequence similarities. Our Boster Guarantee covers the use of this product with the above species.
*Our Boster Guarantee covers the use of this product in the above tested applications.
*Innovating Scientists reward: if you test this antibody on a species or application not listed above and share with us your results, we will provide you a full credit to purchase Boster products.
|Related Products||Boster recommends Enhanced Chemiluminescent Kit with anti-Rabbit IgG (EK1002) for Western blot.
*Blocking peptide can be purchased at $50. Contact us for more information.
**Boster also offers various secondary antibodies for Immunoflourescecne and IHC. Take advantage of the buy 1 primary antibody get 1 secondary antibody for free promotion all year round.
|Immunogen||A synthetic peptide corresponding to a sequence in the middle region of mouse CCR4(346-360aa, SYTQSTVDHDFRDAL), identical to the related rat sequence.|
|Cross Reactivity||No cross reactivity with other proteins|
Gene/Protein Basic Information For Ccr4 (Source: Uniprot.org, NCBI)
|NCBI Gene Id||12773|
|Species Of This Entry||Mouse|
|Protein Name||C-C chemokine receptor type 4|
|Superfamily||G-protein coupled receptor 1 family|
|Alternative Names||Ccr4|C-C chemokine receptor type 4; C-C CKR-4; CC-CKR-4HGCN:14099; CCR4; CCR-4; CD194 antigen; CD194; chemokine (C-C motif) receptor 4; chemokine (C-C) receptor 4; ChemR13; CKR4MGC88293; CMKBR4k5-5; K5-5|
|Post Tranlational Modifications||Phosphorylation; Cleavage; Methylation; Ubiquitination; Acetylation; Demethylation; Nitration; Biotinylation; Reduction|
|Gene Location||9 F3|9 64.49 cM, on Chromasome 9, gene sequence:|
*if product is indicated to react with multiple species, protein info is based on the gene entry specified above in "species".
Ontology For Ccr4 (Source: Uniprot.org, NCBI)
|Protein Function||High affinity receptor for the C-C type chemokines CCL17/TARC and CCL22/MDC. The activity of this receptor is mediated by G(i) proteins which activate a phosphatidylinositol- calcium second messenger system. Could play a role in lipopolysaccharide (LPS)-induced endotoxic shock. In the CNS, could mediate hippocampal-neuron survival.|
|Tissue Specificity||Expressed in the thymus, macrophages and T- and B-cells.|
|Research Areas||Chemokines and Cytokines; Cytokine Research; GPCR; Immunology; Innate Immunity; Signal Transduction|
|Related Diseases||Inflammation; Cholangiocarcinoma; Neoplasms; Dermatitis; Asthma; Malignant Neoplasms; Lymphoma; Dermatitis, Atopic; Hiv Infections; Autoimmune Reaction; Adult T-cell Lymphoma/leukemia; Tissue Adhesions; Allergy; T-cell Lymphoma; Arthritis; Immunologic Deficiency Syndromes; Skin Neoplasms; Sclerosis; Autoimmune Diseases; Malignant Paraganglionic Neoplasm|
|Related Pathways||Pathogenesis; Chemotaxis; Immune Response; Secretion; Cytokine Production; Cell Migration; Localization; Translation; Hypersensitivity; Cell Proliferation; Cell Activation; Chemokine Production; T Cell Activation; Sensitization; Cell Cycle; Cell Differentiation; Antibody-dependent Cellular Cytotoxicity; T Cell Migration; Inflammatory Response; Cytokine Secretion|
|Background||CCR4,C-C chemokine receptor type 4 is a protein that in humans is encoded by the CCR4 gene. CCR4 has also recently been designated CD194(cluster of differentiation 194). The protein encoded by this gene belongs to the G protein-coupled receptor family. It is a receptor for the following CC chemokines. The CCR4 gene is mapped to chromosome 3. Chemokines are a group of small structurally related proteins that regulate cell trafficking of various types of leukocytes. The chemokines also play fundamental roles in the development, homeostasis, and function of the immune system, and they have effects on cells of the central nervous system as well as on endothelial cells involved in angiogenesis or angiostasis.|
|Scientific References||PMID: 8573157 by Hoogewerf A.J., et al. Molecular cloning of murine CC CKR-4 and high affinity binding of chemokines to murine and human CC CKR-4.|
PMID: 9192769 by Youn B.-S., et al. Molecular cloning and characterization of a cDNA, CHEMR1, encoding a chemokine receptor with a homology to the human C-C chemokine receptor, CCR-4.
Our Boster Quality Guarantee for Anti-C-C chemokine receptor type 4 CCR4 Antibody covers its use in the following applications.Western blot, 0.1-0.5μg/ml, Mouse, Rat
*The recommended dilution ratios/concentrations are for reference only and optimal dilutions/concentrations should be determined by the end user.
All lanes: Anti CCR4 (PA1517) at 0.5ug/ml
Lane 1: Rat Thymus Tissue Lysate at 50ug
Lane 2: Rat Spleen Tissue Lysate at 50ug
Lane 3: HEPA Whole Cell Lysate at 40ug
Predicted bind size: 41KD
Observed bind size: 41KD
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