Chromodomain-helicase-DNA-binding protein 1 (CHD1)

ATP-dependent chromatin-remodeling factor which serves as substrate recognition component of the transcription regulatory histone acetylation (HAT) complex SAGA. Also required for efficient transcription by RNA polymerase I, and more specifically the polymerase I transcription termination step.

Regulates negatively DNA replication. Not only involved in transcription-related chromatin-remodeling, but also required to maintain a particular chromatin configuration across the genome.