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- Table of Contents
CHD1 Antibodies
AND CHD1 ELISA kits, CHD1 Proteins
Many biological assays use antibodies to detect CHD1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with CHD1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop CHD1 antibodies...
Designing a Western blot for CHD1? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the CHD1 Western Blot GuideDesigning an IHC experiment for CHD1? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.
Open the CHD1 IHC GuideCHD1 Infographic by Boster Bio
All CHD1 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
ELISA, Flow Cytometry, IHC, WB
$370
Cat # A01175-1
100 μg/vial
Cat # A01175-1
100 μg/vial
Human, Mouse
Flow Cytometry, IP, IF, IHC, ICC, WB
$370
Cat # M05749-1
100 μl/vial
Cat # M05749-1
100 μl/vial
Human, Mouse, Rat
ELISA, IP, IF, IHC, ICC, WB
$370
Cat # A05749-2
100 μg/vial
Cat # A05749-2
100 μg/vial
CHD1 Overview
Facts about Chromodomain-helicase-DNA-binding protein 1.
Chromodomain-helicase-DNA-binding protein 1 (CHD1)
ATP-dependent chromatin-remodeling factor which serves as substrate recognition component of the transcription regulatory histone acetylation (HAT) complex SAGA. Also required for efficient transcription by RNA polymerase I, and more specifically the polymerase I transcription termination step.
Regulates negatively DNA replication. Not only involved in transcription-related chromatin-remodeling, but also required to maintain a particular chromatin configuration across the genome.
Gene Information
| Human | |
|---|---|
| Gene Name: | CHD1 |
| Uniprot: | O14646 |
| Entrez: | 1105 |
Family
| Belongs to: |
|---|
| SNF2/RAD54 helicase family |
Alternative Names
ATP-dependent helicase CHD1; CHD1; CHD-1; chromodomain helicase DNA binding protein 1; chromodomain-helicase-DNA-binding protein 1; DKFZp686E2337; EC 3.6.1; EC 3.6.4.12
Molecular Weight
Mass (kDA):
196.688 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 5q15-q21.1 |
| Sequence: | 5; NC_000005.10 (98853985..98929772, complement) |
Tissue Specificity
Expressed in many tissues including in the brain, where the highest level of expression is found in the cerebellum and basal ganglia.
Subcellular Localizations
Nucleus. Cytoplasm. Is released into the cytoplasm when cells enter mitosis and is reincorporated into chromatin during telophase-cytokinesis.
Diseases
- Malignant Neoplasms
- Neoplasms
- Stomach Neoplasms
- Prostatic Neoplasms
- Malignant Neoplasm Of Prostate
- Malignant Neoplasm Of Stomach
- Malignant Neoplasm Of Breast
- Carcinoma
- Mammary Neoplasms
- Cell Transformation, Neoplastic
- Hiv Infections
- Leukemia
Pathways
- Chromatin Remodeling
- Methylation
- Atp-dependent Chromatin Remodeling
- Chromatin Assembly
- Histone Modification
- Localization
- Chromatin Organization
- Dna Methylation
- Histone Acetylation
- Histone Methylation
- Rna Interference
- Nucleosome Positioning
- Dna Replication
PTMs
- Methylation
- Phosphorylation
- Acetylation
- Deacetylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/CHD1
bosterbio.com/bosterbio-gene-info-cards/CHD1
References
PMID: 9326634 by Woodage T., et al. Characterization of the CHD family of proteins.
PMID: 16263726 by Sims R.J. III, et al. Human but not yeast CHD1 binds directly and selectively to histone H3 methylated at lysine 4 via its tandem chromodomains.