CHD1 Infographic
Chromodomain-helicase-DNA-binding protein 1 Info At a glance, species: Human
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Chromodomain-helicase-DNA-binding protein 1 (CHD1)
ATP-dependent chromatin-remodeling factor which serves as substrate recognition component of the transcription regulatory histone acetylation (HAT) complex SAGA. Also required for efficient transcription by RNA polymerase I, and more specifically the polymerase I transcription termination step.
Regulates negatively DNA replication. Not only involved in transcription-related chromatin-remodeling, but also required to maintain a particular chromatin configuration across the genome.
Gene Information
| Human | |
|---|---|
| Gene Name: | CHD1 |
| Uniprot: | O14646 |
| Entrez: | 1105 |
Family
| Belongs to: |
|---|
| SNF2/RAD54 helicase family |
Alternative Names
ATP-dependent helicase CHD1; CHD1; CHD-1; chromodomain helicase DNA binding protein 1; chromodomain-helicase-DNA-binding protein 1; DKFZp686E2337; EC 3.6.1; EC 3.6.4.12
Molecular Weight
Mass (kDA):
196.688 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 5q15-q21.1 |
| Sequence: | 5; NC_000005.10 (98853985..98929772, complement) |
Tissue Specificity
Expressed in many tissues including in the brain, where the highest level of expression is found in the cerebellum and basal ganglia.
Subcellular Localizations
Nucleus. Cytoplasm. Is released into the cytoplasm when cells enter mitosis and is reincorporated into chromatin during telophase-cytokinesis.
Diseases
- Malignant Neoplasms
- Neoplasms
- Stomach Neoplasms
- Prostatic Neoplasms
- Malignant Neoplasm Of Prostate
- Malignant Neoplasm Of Stomach
- Malignant Neoplasm Of Breast
- Carcinoma
- Mammary Neoplasms
- Cell Transformation, Neoplastic
- Hiv Infections
- Leukemia
Pathways
- Chromatin Remodeling
- Methylation
- Atp-dependent Chromatin Remodeling
- Chromatin Assembly
- Histone Modification
- Localization
- Chromatin Organization
- Dna Methylation
- Histone Acetylation
- Histone Methylation
- Rna Interference
- Nucleosome Positioning
- Dna Replication
PTMs
- Methylation
- Phosphorylation
- Acetylation
- Deacetylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/CHD1
bosterbio.com/bosterbio-gene-info-cards/CHD1
References
PMID: 9326634 by Woodage T., et al. Characterization of the CHD family of proteins.
PMID: 16263726 by Sims R.J. III, et al. Human but not yeast CHD1 binds directly and selectively to histone H3 methylated at lysine 4 via its tandem chromodomains.