CRADD Antibodies

AND CRADD ELISA kits, CRADD Proteins

Many biological assays use antibodies to detect CRADD, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with CRADD in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop CRADD antibodies...

We validate the specificity of these antibodies to CRADD by testing them on tissues known to express CRADD positively and negatively. Browse below to find the CRADD antibody that suites your experiment. We have 7 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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CRADD Infographic by Boster Bio

All CRADD Products

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Specificity

Applications

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Anti-RAIDD Rabbit Monoclonal Antibody

3 Q&As

Western blot analysis of RAIDD expression in HeLa cell lysate

Human

Flow Cytometry, IP, IF, IHC, ICC, WB

$370
Cat # M06509-1
100 μl

Anti-RAIDD CRADD Antibody

Western blot analysis of RAIDD in whole cell lysates from HeLa (H) or K562 (K) cells with RAIDD antibody at 1:500 dilution

Immunocytochemistry of RAIDD in HeLa cells with RAIDD antibody at 5 μg/mL

Immunofluorescence of RAIDD in Hela cells with RAIDD antibody at 20 μg/mL

Human

ELISA, IF, ICC, WB

$481
Cat # A06509-1
0.1 mg

Anti-RAIDD CRADD Antibody

Western blot (WB) analysis of RAIDD polyclonal antibody at 1:500 dilution
Lane1:MCF-7 whole cell lysate
Lane2:sp2/0 whole cell lysate
Lane3:PC12 whole cell lysate

Human, Mouse, Rat

$405
Cat # A06509-2
100ul

RAIDD (CRADD) (NM_003805) Human Recombinant Protein

Coomassie blue staining of purified CRADD protein

$1249
Cat # PROTP78560
20 µg

Anti-RAIDD Rabbit Monoclonal Antibody

Human, Rat

Flow Cytometry, IP, IF, ICC, WB

$370
Cat # M06509-2
100 μl/vial

RAIDD (CRADD) (NM_003805) Human Over-expression Lysate

Human

$628
Cat # LS008738
20 µg, 100 µg

Anti-RAIDD/CRADD Antibody

Human, Mouse, Rat

ELISA, IP, IHC, WB

$370
Cat # A06509-3
100 μl/vial

CRADD Overview

Facts about Death domain-containing protein CRADD.

CRADD 3D structure. Source: alphafold

Death domain-containing protein CRADD (CRADD)

Adapter protein that associates with PIDD1 and the caspase CASP2 to form the PIDDosome, a complex that activates CASP2 and triggers apoptosis (PubMed:9044836, PubMed:15073321, PubMed:16652156, PubMed:17159900, PubMed:17289572). Also recruits CASP2 to the TNFR-1 signaling complex through its interaction with RIPK1 and TRADD and might play a role in the tumor necrosis factor- mediated signaling pathway (PubMed:8985253).

Gene Information

Human
Gene Name:	CRADD
Uniprot:	P78560
Entrez:	8738

Family

Belongs to:

No superfamily

Alternative Names

CASP2 and RIPK1 domain containing adaptor with death domain; Caspase and RIP adapter with death domain; caspase and RIP adaptor with death domain; CRADD; death domain containing protein CRADD; death domain-containing protein CRADD; MGC9163; RAIDD; RAIDDdeath adaptor molecule RAIDD; RIP-associated ICH1/CED3-homologous protein with death domain; RIP-associated protein with a death domain

Molecular Weight

Mass (kDA):
22.745 kDA

Genomic Context


Human

Location:	12q22
Sequence:	12; NC_000012.12 (93677342..93894840)

Tissue Specificity

Constitutively expressed in most tissues, with particularly high expression in adult heart, testis, liver, skeletal muscle, fetal liver and kidney.

Subcellular Localizations

Cytoplasm. Nucleus.

Diseases

Malignant Neoplasms
Neoplasms
Carcinoma
Genotoxic Stress
Denys-drash Syndrome
Cell Transformation, Neoplastic
Lymphoma
Physiological Stress
Neuroblastoma
Malignant Squamous Cell Neoplasm
Obesity
Leukemia

Acquired Immunodeficiency Syndrome
Non-neoplastic Disorder
Kidney Neoplasm
Churg-strauss Syndrome
Mouth Neoplasms
Severe Combined Immunodeficiency
Myeloid Leukemia

Interacting Proteins

ACTN2
APPL2
BBS5
CASP2
KCTD9

PIDD1
TRIM54

Pathways

Cell Death
Induction Of Apoptosis
Localization
Cell Cycle
Apoptotic Process
Cell Proliferation
Mitochondrial Outer Membrane Permeabilization
Response To Heat
Cell Cycle Arrest
Sensitization

Apoptotic Dna Fragmentation
Cell Differentiation
Pathogenesis
Organ Formation
Granuloma Formation

PTMs

Cleavage
Sumoylation

Biotinylation
Ubiquitination

Research Areas

Apoptosis
Cancer
Cell Biology
Tumor Suppressors

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/CRADD

References

PMID: 9044836 by Ahmad M., et al. CRADD, a novel human apoptotic adaptor molecule for caspase-2, and FasL/tumor necrosis factor receptor-interacting protein RIP.

PMID: 8985253 by Duan H., et al. RAIDD is a new 'death' adaptor molecule.