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The anisotropic distribution of CRB2 and MYH10/myosin-IIB at cell edges specify which cells will ingress: cells with high apical CRB2 are probably extruded from the epiblast by neighboring cells with elevated levels of apical MYH10/myosin-IIB (PubMed:27870829). Also required for maintenance of the apical polarity complex during development of the cortex.
|Crumbs protein family|
In the adult eye, strongly expressed in the outer nuclear layer, containing the cell bodies of the photoreceptor cells, and in the inner nuclear layer, containing the cell bodies of the horizontal, bipolar, amacrine, and Mueller glial cells (PubMed:15851977). Also expressed in some cells in the ganglion cell layer (or may be displaced amacrine cells rather than ganglion cells) (PubMed:15851977).