CTU1 Infographic
Cytoplasmic tRNA 2-thiolation protein 1 Info At a glance, species: Human
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Cytoplasmic tRNA 2-thiolation protein 1 (CTU1)
Plays a central role in 2-thiolation of mcm(5)S(2)U in tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). Directly binds tRNAs and probably acts by catalyzing adenylation of tRNAs, an intermediate required for 2-thiolation.
It's unclear whether it acts as a sulfurtransferase that transports sulfur from thiocarboxylated URM1 on the uridine of tRNAs at wobble position. .
Gene Information
| Human | |
|---|---|
| Gene Name: | CTU1 |
| Uniprot: | Q7Z7A3 |
| Entrez: | 90353 |
Family
| Belongs to: |
|---|
| TtcA family |
Alternative Names
ATP binding domain 3; ATPBD3cancer-associated protein; Cancer-associated gene protein; cytoplasmic tRNA 2-thiolation protein 1; Cytoplasmic tRNA adenylyltransferase 1; cytosolic thiouridylase subunit 1 homolog (S. pombe); EC 2.7.7; EC 2.7.7.-; MGC17332; NCS6ATP-binding domain-containing protein 3
Molecular Weight
Mass (kDA):
36.45 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 19q13.41 |
| Sequence: | 19; NC_000019.10 (51097606..51108409, complement) |
Subcellular Localizations
Cytoplasm.
Interacting Proteins
- URM1
Pathways
- Programmed Cell Death
- Cell Death
PTMs
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/CTU1
bosterbio.com/bosterbio-gene-info-cards/CTU1
References
PMID: 19017811 by Schlieker C.D., et al. A functional proteomics approach links the ubiquitin-related modifier Urm1 to a tRNA modification pathway.
