Cytoplasmic tRNA 2-thiolation protein 1 (CTU1)
Plays a central role in 2-thiolation of mcm(5)S(2)U in tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). Directly binds tRNAs and probably acts by catalyzing adenylation of tRNAs, an intermediate required for 2-thiolation.
It's unclear whether it acts as a sulfurtransferase that transports sulfur from thiocarboxylated URM1 on the uridine of tRNAs at wobble position. .
ATP binding domain 3; ATPBD3cancer-associated protein; Cancer-associated gene protein; cytoplasmic tRNA 2-thiolation protein 1; Cytoplasmic tRNA adenylyltransferase 1; cytosolic thiouridylase subunit 1 homolog (S. pombe); EC 2.7.7; EC 2.7.7.-; MGC17332; NCS6ATP-binding domain-containing protein 3
|Sequence:||19; NC_000019.10 (51097606..51108409, complement)|
- Programmed Cell Death
- Cell Death