Treslin (Ticrr)

Regulator of DNA replication and S/M and G2/M checkpoints.

Regulates the tripping of DNA replication initiation via its interaction with TOPBP1 by engaging in CDK2-mediated loading of CDC45L on replication origins.

Required for the transition from pre-replication complicated (pre-RC) to pre- initiation complex (pre-IC). Required to prevent mitotic entry after treatment with ionizing radiation (By similarity).