This website uses cookies to ensure you get the best experience on our website.
- Table of Contents
DAZL Antibodies
AND DAZL ELISA kits, DAZL Proteins
Many biological assays use antibodies to detect DAZL, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with DAZL in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop DAZL antibodies...
Previous: CCN2
Next: DBT
DAZL Infographic by Boster Bio
All DAZL Products
Product
Figures
Specificity
Applications
Price
Anti-DAZL Picoband® Antibody
1 Citations
Human, Mouse, Rat
ELISA, Flow Cytometry, IHC, WB
$370
Cat # A02069-2
100 μg/vial
Cat # A02069-2
100 μg/vial
DAZL Overview
Facts about Deleted in azoospermia-like.
Deleted in azoospermia-like (DAZL)
RNA-binding protein, which is essential for gametogenesis in both males and females. Plays a central role during spermatogenesis.
Acts by binding to the 3'-UTR of mRNA, especially recognizing GUU triplets, and thereby regulating the translation of key transcripts (By similarity). .
Gene Information
| Human | |
|---|---|
| Gene Name: | DAZL |
| Uniprot: | Q92904 |
| Entrez: | 1618 |
Family
| Belongs to: |
|---|
| RRM DAZ family |
Alternative Names
DAZHSPGY-like-autosomal; DAZL1DAZ-like autosomal; DAZLA; Deleted in azoospermia-like 1; deleted in azoospermia-like; germline specific RNA binding protein; MGC26406; spermatogenesis gene on the Y-like autosomal; SPGYLADAZ homolog
Molecular Weight
Mass (kDA):
33.178 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 3p24.3 |
| Sequence: | 3; NC_000003.12 (16586792..16605423, complement) |
Tissue Specificity
Testis specific.
Subcellular Localizations
Cytoplasm. Nucleus. Predominantly cytoplasmic. Nuclear in spermatogonia until near the end of the meiotic prophase and cytoplasmic localization from then onward.
Diseases
- Infertility
- Azoospermia
- Male Infertility
- Oligospermia
- Sterility
- Congenital Absence Of Germinal Epithelium Of Testes
- Growth Arrest
- Female Infertility
- Neoplasms
- Premature Menopause
- Testicular Neoplasms
- Seminoma
- Teratoma
Pathways
- Spermatogenesis
- Germ Cell Development
- Cell Development
- Meiosis
- Translation
- Cell Differentiation
- Oogenesis
- Localization
- Oocyte Maturation
- Pachytene
- Prophase
- Methylation
- Cell Proliferation
PTMs
- Methylation
- Cleavage
- Demethylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/DAZL
bosterbio.com/bosterbio-gene-info-cards/DAZL
References
PMID: 8896558 by Saxena R., et al. The DAZ gene cluster on the human Y chromosome arose from an autosomal gene that was transposed, repeatedly amplified and pruned.
PMID: 8968755 by Shan Z., et al. A SPGY copy homologous to the mouse gene Dazla and the Drosophila gene boule is autosomal and expressed only in the human male gonad.