DDIT3 upstream open reading frame protein (DDIT3)

Plays an important role in the response to a vast array of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress. Plays a dual role both as an inhibitor of CCAAT/enhancer-binding protein (C/EBP) function and as an activator of different genes.

Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of their C/EBP family, impairs their affiliation with C/EBP binding sites in the promoter regions, and inhibits the expression of C/EBP regulated genes. Positively regulates the transcription of TRIB3, IL6, IL8, IL23, TNFRSF10B/DR5, PPP1R15A/GADD34, BBC3/PUMA, BCL2L11/BIM and ERO1L.