Discoidin domain-containing receptor 2 (DDR2)

Tyrosine kinase that acts as cell surface receptor for fibrillar collagen and modulates cell differentiation, remodeling of the extracellular matrix, cell migration and cell proliferation. Required for normal bone growth.

Regulates osteoblast differentiation and chondrocyte maturation with a signaling pathway that involves MAP kinases and leads to the activation of this transcription factor RUNX2. Regulates remodeling of the extracellular matrix from up-regulation of the collagenases MMP1, MMP2 and MMP13, and thereby facilitates cell migration and tumor cell invasion.