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Regulates osteoblast differentiation and chondrocyte maturation with a signaling pathway that involves MAP kinases and leads to the activation of this transcription factor RUNX2. Regulates remodeling of the extracellular matrix from up-regulation of the collagenases MMP1, MMP2 and MMP13, and thereby facilitates cell migration and tumor cell invasion.
|protein kinase superfamily|
|Sequence:||1; NC_000001.11 (162630863..162787405)|
Detected in osteocytes, osteoblastic cells in subchondral bone, bone lining cells, tibia and cartilage (at protein level). Detected at high levels in heart and lung, and at low levels in brain, placenta, liver, skeletal muscle, pancreas, and kidney.
Cell membrane; Single-pass type I membrane protein.