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Positively regulates the sperm motility and bactericidal activity in a CCR6-dependent method. Binds to CCR6 and activates Ca2+ mobilization from the sperm which is very important to its motility (PubMed:25122636).
|Sequence:||8; NC_000008.11 (6870592..6877936, complement)|
Blood plasma. Sperm. Highly expressed in the lower head and midpiece of sperm. Significantly reduced levels found in the sperms of asthenozoospermia and leukocytospermia patients (at protein level).
Secreted. Membrane. Associates with tumor cell membrane-derived microvesicles (PubMed:23938203).