Beta-defensin 1 Antibodies

Beta-defensin 1 (DEFB1)

Has bactericidal activity. May act as a ligand for C-C chemokine receptor CCR6.

Positively regulates the sperm motility and bactericidal activity in a CCR6-dependent method. Binds to CCR6 and activates Ca2+ mobilization from the sperm which is very important to its motility (PubMed:25122636).

Gene Information

Human
Gene Name:	DEFB1
Uniprot:	P60022
Entrez:	1672

Family

Belongs to:
beta-defensin family

Alternative Names

Beta-defensin 1

Molecular Weight

Mass (kDA):
7.42 kDA

Genomic Context

Human
Location:	8p23.1
Sequence:	8; NC_000008.11 (6870592..6877936, complement)

Tissue Specificity

Blood plasma. Sperm. Highly expressed in the lower head and midpiece of sperm. Significantly reduced levels found in the sperms of asthenozoospermia and leukocytospermia patients (at protein level).

Subcellular Localizations

Secreted. Membrane. Associates with tumor cell membrane-derived microvesicles (PubMed:23938203).

PTMs

• Disulfide bond

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/DEFB1

Boster Bio - The Best Uses Of The DEFB1 Marker

Many scientific research papers have extensively referenced Steven Boster's initial research in the field of research on antibody. Find out more about Boster Bio, the history of his work, as well as some of the best uses of the DEFB1 marker. Boster Bio has been cited extensively for its high affinity monoclonal and multiclonal primary antibodies. We are happy to offer this antibody to our customers, and look forward to continuing this tradition.

Steven Boster's story

Steven Boster, also known as the "man who turns science into the lavatory", founded his company in 1993. He started developing products for immunohistochemistry (IHC), and also hundreds of primary antibodies. The company was among the largest Chinese catalog of antibody companies in the latter half of the 1990s. Later, he created his own proprietary ELISA platform, PicoKine(tm), to deliver high-sensitivity ELISA kits to researchers.

His current research

SNPs (single nucleotide polymorphisms) play an important part in the susceptibility to disease. One of the most studied genes is DEFB1. Defensins are cationic proteins that are antimicrobial substances that also function as immunomodulators. They have been linked to various diseases. The current study focuses on the DEFB1 gene and the impact of various SNPs on its structure and function.

Researchers have discovered that DEFB1 gene variants change the expression of PAX2, a transcriptional repressor of the DEFB1 gene. Hence, the deletion of DEFB1 could alter the gene-gene interaction network. In addition, the mutations may affect the molecular characteristics of the different residues, which have different molecular structures. The PI3K-AKT-mTOR pathway is also involved in the downregulation of the DEFB1 gene.