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- Table of Contents
EIF3B Antibodies
AND EIF3B ELISA kits, EIF3B Proteins
Many biological assays use antibodies to detect EIF3B, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with EIF3B in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop EIF3B antibodies...
Designing a Western blot for EIF3B? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the EIF3B Western Blot GuideDesigning an IHC experiment for EIF3B? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.
Open the EIF3B IHC GuideEIF3B Infographic by Boster Bio
All EIF3B Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
ELISA, Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # A04318-1
100 µg/vial
Cat # A04318-1
100 µg/vial
Human, Mouse, Rat
Flow Cytometry, IP, IF, ICC, WB
$370
Cat # M04318
100 μl/vial
Cat # M04318
100 μl/vial
EIF3B Overview
Facts about Eukaryotic translation initiation factor 3 subunit B.
Eukaryotic translation initiation factor 3 subunit B (EIF3B)
RNA-binding part of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for many steps in the initiation of protein synthesis (PubMed:9388245, PubMed:17581632, PubMed:25849773, PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complicated (43S PIC).
The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and then prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:9388245, PubMed:17581632).
Gene Information
| Human | |
|---|---|
| Gene Name: | EIF3B |
| Uniprot: | P55884 |
| Entrez: | 8662 |
Family
| Belongs to: |
|---|
| eIF-3 subunit B family |
Alternative Names
eIF3 p110; eIF3 p116; eIF3b; eIF-3-eta; EIF3-P110; EIF3-P116; EIF3S9EIF3-ETA; Eukaryotic translation initiation factor 3 subunit 9; eukaryotic translation initiation factor 3 subunit B; eukaryotic translation initiation factor 3, subunit 9 (eta, 116kD); eukaryotic translation initiation factor 3, subunit 9 eta, 116kDa; eukaryotic translation initiation factor 3, subunit B; MGC104664; MGC131875; Prt1 homolog; PRT1hPrt1
Molecular Weight
Mass (kDA):
92.482 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 7p22.3 |
| Sequence: | 7; NC_000007.14 (2354086..2380745) |
Subcellular Localizations
Cytoplasm.
Diseases
- Hepatitis
- Hepatitis C
- Neoplasms
- Cytopathic Effect
- Classical Swine Fever
- African Swine Fever
- Glioblastoma
- Malignant Tumor Of Colon
- Glioma
- Punctate Inner Choroidopathy
- Foot-and-mouth Disease
- Physiological Stress
Interacting Proteins
- DDX3X
- EIF3A
- EIF3E
- EIF3F
- EIF3G
- EIF3H
- EIF3I
- EIF3J
- EIF3K
- EIF3L
Pathways
- Translation
- Proteolysis
- Rna Interference
- Cell Proliferation
- Cell Death
- Cell Cycle
- Photomorphogenesis
- G1 Phase
- Cell Growth
PTMs
- Phosphorylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/EIF3B
bosterbio.com/bosterbio-gene-info-cards/EIF3B
References
PMID: 9388245 by Chaudhuri J., et al. Biochemical characterization of mammalian translation initiation factor 3 (eIF3). Molecular cloning reveals that p110 subunit is the mammalian homologue of Saccharomyces cerevisiae protein Prt1.
PMID: 8995410 by Methot N., et al. The human homologue of the yeast Prt1 protein is an integral part of the eukaryotic initiation factor 3 complex and interacts with p170.