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EIF3D Antibodies
AND EIF3D ELISA kits, EIF3D Proteins
Many biological assays use antibodies to detect EIF3D, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with EIF3D in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop EIF3D antibodies...
Designing a Western blot for EIF3D? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the EIF3D Western Blot GuideDesigning an IHC experiment for EIF3D? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.
Open the EIF3D IHC GuideEIF3D Infographic by Boster Bio
All EIF3D Products
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EIF3D Overview
Facts about Eukaryotic translation initiation factor 3 subunit D.
Eukaryotic translation initiation factor 3 subunit D (EIF3D)
MRNA cap-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, a complex required for many steps in the initiation of protein synthesis of a technical repertoire of mRNAs (PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC).
The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:18599441, PubMed:25849773).
Gene Information
| Human | |
|---|---|
| Gene Name: | EIF3D |
| Uniprot: | O15371 |
| Entrez: | 8664 |
Family
| Belongs to: |
|---|
| eIF-3 subunit D family |
Alternative Names
eIF3d; eIF3-p66; EIF3S7eIF3 p66; eIF-3-zeta; eIF3-zeta; Eukaryotic translation initiation factor 3 subunit 7; eukaryotic translation initiation factor 3 subunit D; eukaryotic translation initiation factor 3, subunit 7 zeta, 66/67kDa; eukaryotic translation initiation factor 3, subunit D; MGC126526; MGC17258; translation initiation factor eIF3 p66 subunit
Molecular Weight
Mass (kDA):
63.973 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 22q12.3 |
| Sequence: | 22; NC_000022.11 (36510855..36529166, complement) |
Subcellular Localizations
Cytoplasm.
Diseases
- Immunologic Deficiency Syndromes
- Malignant Mesothelioma
- Cell Transformation, Neoplastic
- Malignant Neoplasms
- Neoplasms
- Hiv Infections
- Pleural Neoplasms
Interacting Proteins
- BEND5
- EIF3E
- HOMER3
- LZTS2
- MORN3
- PHLDA1
- REL
- SAT1
- TRIM27
Pathways
- Translation
- Cell Proliferation
- Proteolysis
- Meiosis
- Chromosome Segregation
PTMs
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/EIF3D
bosterbio.com/bosterbio-gene-info-cards/EIF3D
References
PMID: 9341143 by Asano K., et al. Structure of cDNAs encoding human eukaryotic initiation factor 3 subunits. Possible roles in RNA binding and macromolecular assembly.
PMID: 12773399 by Daughenbaugh K.F., et al. The genome-linked protein VPg of the Norwalk virus binds eIF3, suggesting its role in translation initiation complex recruitment.