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The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and then prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17581632). The eIF- 3 complex especially targets and initiates translation of a subset of mRNAs involved in cell proliferation, including mobile cycling, differentiation and apoptosis, and uses different styles of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773).
|eIF-3 subunit E family|
|Sequence:||8; NC_000008.11 (108201216..108248734, complement)|
Ubiquitously expressed. Expressed at highest levels in appendix, lymph, pancreas, skeletal muscle, spleen and thymus.
Cytoplasm. Nucleus, PML body.