Eukaryotic translation initiation factor 3 subunit E (EIF3E)

Part of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773, PubMed:27462815). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition.

The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and then prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17581632). The eIF- 3 complex especially targets and initiates translation of a subset of mRNAs involved in cell proliferation, including mobile cycling, differentiation and apoptosis, and uses different styles of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773).