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- Table of Contents
IRF6 Antibodies
AND IRF6 ELISA kits, IRF6 Proteins
Many biological assays use antibodies to detect IRF6, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with IRF6 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop IRF6 antibodies...
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IRF6 Infographic by Boster Bio
All IRF6 Products
Product
Figures
Specificity
Applications
Price
Anti-IRF6 Rabbit Monoclonal Antibody
1 Citations 6 Q&As
Human, Mouse, Rat
IF, IHC, ICC, WB
$370
Cat # M01822
100 μl
Cat # M01822
100 μl
Human, Mouse, Rat
IF, IHC, ICC, WB
$405
Cat # A01822-1
100ul
Cat # A01822-1
100ul
Dog, Human, Mouse, Rat
Flow Cytometry, IF, IHC, WB
$523
Cat # M01822-1
100 µl
Cat # M01822-1
100 µl
IRF6 Overview
Facts about Interferon regulatory factor 6.
Interferon regulatory factor 6 (IRF6)
Probable DNA-binding transcriptional activator. Key determinant of the keratinocyte proliferation-differentiation switch involved in appropriate epidermal development (By similarity).
Plays a role in regulating mammary epithelial cell proliferation (By similarity). May regulate WDR65 transcription (By similarity).
Gene Information
| Human | |
|---|---|
| Gene Name: | IRF6 |
| Uniprot: | O14896 |
| Entrez: | 3664 |
Family
| Belongs to: |
|---|
| IRF family |
Alternative Names
interferon regulatory factor 6; IRF6; IRF-6; LPS; OFC6; OFC6PPS; PIT; PPS; Van der Woude syndrome; VWS; VWS1
Molecular Weight
Mass (kDA):
53.13 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 1q32.2 |
| Sequence: | 1; NC_000001.11 (209785617..209806175, complement) |
Tissue Specificity
Expressed in normal mammary epithelial cells. Expression is reduced or absent in breast carcinomas.
Subcellular Localizations
Nucleus. Cytoplasm. Translocates to nucleus in response to an activating signal.
Diseases
- Cleft Palate
- Cleft Lip
- Van Der Woude Syndrome
- Congenital Abnormality
- Cleft Palate With Cleft Lip
- Pterygium
- Dysequilibrium Syndrome
- Popliteal Pterygium Syndrome
- Multiple Pterygium Syndrome
- Malignant Neoplasms
- Neoplasms
- Hypodontia
Interacting Proteins
- IRF8
Pathways
- Cell Cycle
- Pathogenesis
- Localization
- Translation
- Cell Differentiation
- Epithelial Cell Differentiation
- Cell Adhesion
- Developmental Process
- Immune Response
- Mammary Gland Development
- Keratinocyte Differentiation
- Palate Development
- Gastrulation
PTMs
- Phosphorylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/IRF6
bosterbio.com/bosterbio-gene-info-cards/IRF6
References
PMID: 16049006 by Bailey C.M., et al. Mammary serine protease inhibitor (Maspin) binds directly to interferon regulatory factor 6: identification of a novel serpin partnership.
PMID: 18212048 by Bailey C.M., et al. Interferon regulatory factor 6 promotes cell cycle arrest and is regulated by the proteasome in a cell cycle-dependent manner.