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- Table of Contents
EIF4A2 Antibodies
AND EIF4A2 ELISA kits, EIF4A2 Proteins
Many biological assays use antibodies to detect EIF4A2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with EIF4A2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop EIF4A2 antibodies...
Designing a Western blot for EIF4A2? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the EIF4A2 Western Blot GuideDesigning an IHC experiment for EIF4A2? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.
Open the EIF4A2 IHC GuideEIF4A2 Infographic by Boster Bio
All EIF4A2 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
Flow Cytometry, IP, IF, IHC, IHC-F, ICC, WB
$370
Cat # PB9758
100 μg/vial
Cat # PB9758
100 μg/vial
EIF4A2 Overview
Facts about Eukaryotic initiation factor 4A-II.
Eukaryotic initiation factor 4A-II (EIF4A2)
ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon.
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Gene Information
| Human | |
|---|---|
| Gene Name: | EIF4A2 |
| Uniprot: | Q14240 |
| Entrez: | 1974 |
Family
| Belongs to: |
|---|
| DEAD box helicase family |
Alternative Names
ATP-dependent RNA helicase eIF4A-2; BM-010; DDX2Beukaryotic translation initiation factor 4A, isoform 2; EC 3.6.1; EC 3.6.4.13; EIF4A; eIF-4A-II; eIF4A-II; EIF4F; eukaryotic initiation factor 4A-II; eukaryotic translation initiation factor 4A; eukaryotic translation initiation factor 4A2
Molecular Weight
Mass (kDA):
46.402 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 3q27.3 |
| Sequence: | 3; NC_000003.12 (186783577..186789897) |
Diseases
- Malignant Neoplasms
- Neoplasms
- Malignant Paraganglionic Neoplasm
- Diabetes Mellitus
- Diabetes Mellitus, Non-insulin-dependent
- Liver Diseases
- Diabetic Nephropathy
- Mood Disorders
- Ectopic Pregnancy
- Malignant Neoplasm Of Breast
- Pleural Neoplasms
- Malignant Pleural Mesothelioma
Interacting Proteins
- DPPA4
- HSPB1
- IPO11
- MDFI
- PDCD4
- PIH1D2
- SLC16A9
- SSX2IP
- TRIM36
- TRIM39
Pathways
- Translation
- Cell Proliferation
- Localization
- Response To Stress
- Jak-stat Cascade
- Neurogenesis
- Synaptic Transmission
- Regulation Of Gene Expression
- Hepatocyte Proliferation
- Protein Metabolic Process
PTMs
Research Areas
- Cancer
- mTOR Pathway
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/EIF4A2
bosterbio.com/bosterbio-gene-info-cards/EIF4A2
References
PMID: 8521730 by Sudo K., et al. Isolation and mapping of the human EIF4A2 gene homologous to the murine protein synthesis initiation factor 4A-II gene Eif4a2.
PMID: 11408474 by Li W., et al. Eukaryotic initiation factors 4A (eIF4A) and 4G (eIF4G) mutually interact in a 1:1 ratio in vivo.