This website uses cookies to ensure you get the best experience on our website.
- Table of Contents
Facts about Ectonucleotide pyrophosphatase/phosphodiesterase family member 2.
Can hydrolyze, in vitro, bis-pNPP, to some extent pNP-TMP, and barely ATP (PubMed:15769751, PubMed:12176993). Involved in several motility-related processes such as angiogenesis and neurite outgrowth.
Human | |
---|---|
Gene Name: | ENPP2 |
Uniprot: | Q13822 |
Entrez: | 5168 |
Belongs to: |
---|
nucleotide pyrophosphatase/phosphodiesterase family |
ATX; ATXFLJ26803; ATX-X; Autotaxin; autotaxin-t; EC 3.1.4.39; ectonucleotide pyrophosphatase/phosphodiesterase 2; ectonucleotide pyrophosphatase/phosphodiesterase family member 2; E-NPP 2; ENPP2; ENPP-2; Extracellular lysophospholipase D; Lysophosphatidic Acid; LysoPLD; NPP2; PD-IALPHA; PDNP2; PDNP2NPP2; phosphodiesterase I/nucleotide pyrophosphatase 2; plasma lysophospholipase D
Mass (kDA):
98.994 kDA
Human | |
---|---|
Location: | 8q24.12 |
Sequence: | 8; NC_000008.11 (119557085..119673404, complement) |
Detected in blood plasma (at protein level) (PubMed:12176993, PubMed:26371182). Predominantly expressed in brain, placenta, ovary, and small intestine. Expressed in a number of carcinomas such as hepatocellular and prostate carcinoma, neuroblastoma and non-small-cell lung cancer. Expressed in body fluids such as plasma, cerebral spinal fluid (CSF), saliva, follicular and amniotic fluids. Not detected in leukocytes. Isoform 1 is more highly expressed in peripheral tissues than in the central nervous system (CNS). Adipocytes only express isoform 1. Isoform 3 is more highly expressed in the brain than in peripheral tissues.
Secreted.
ENPP2 regulates WNT/b–catenin signaling and is a phosphodiesterase/phospholipase. It plays a positive function in myogenic differentiate. However, its best uses are not yet fully understood. Continue reading to learn more. You'll also learn more on its role in myogenic differentiate. You'll also learn how to use the marker to determine if it is necessary for your research.
Numerous studies have shown that ENPP2 has been overexpressed in cancer cells and plays a key role in cell motility and immune regulation. This enzyme is overexpressed in a number of cancers, and knockout mice of ENPP2 are embryonically lethal. Several inhibitors of autotaxin activity are in use for different diseases and conditions, including arthritis, asthma, and other inflammatory conditions.
Autotaxin is a Phosphodiesterase (EPPP2) that hydrolyzes Lysophosphatidic Acid (LPA), which is a binding agent for specific G-protein-coupled receptors. ATX-LPA signaling plays an essential role in embryonic development. It is also involved in a variety of physiological processes. We have examined the structure of ATX to identify its specific LysoPLD and its function in various processes. The catalytic Domain contains a deep binding groove and a bimetallic activity site.
The MBS2022398 kit is a microwell strip plate ELISA for the detection of Ectonucleotide Pyrophosphatase/Phosphodiesterase 2 (ENPP2) in biological samples. This kit detects native ENPP2 antibodies in tissue homogenates. It also has high specificity, and high sensitivity.
Among its many applications, the ENPP2 marker is useful for research in several areas. Boster Bio has a high-affinity primary antibody against this gene. This antibody has been extensively cited in scientific literature over the last 25 years. These antibodies have been validated on Western blotting, Immunohistochemistry, and ELISA. Boster also has a variety of ENPP variants, including both anti-phosphorylated AND nonphosphorylated versions.
Boster Bio's latest publication describes the ENPP2 gene, and its use in myogenic differentiation. This review includes gene informationgraphics which give basic details about each gene. Boster covers all gene types in both mouse and human. The gene search bar can be used to find specific information. The authors thank Dr. David A. Wolk and suggest future directions for its use.
PMID: 7982964 by Murata J., et al. cDNA cloning of the human tumor motility-stimulating protein, autotaxin, reveals a homology with phosphodiesterases.
PMID: 8586446 by Kawagoe H., et al. Molecular cloning and chromosomal assignment of the human brain-type phosphodiesterase I/nucleotide pyrophosphatase gene (PDNP2).