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- Table of Contents
ENPP3 Antibodies
AND ENPP3 ELISA kits, ENPP3 Proteins
Many biological assays use antibodies to detect ENPP3, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with ENPP3 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop ENPP3 antibodies...
Designing an IHC experiment for ENPP3? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.
Open the ENPP3 IHC GuideENPP3 Infographic by Boster Bio
All ENPP3 Products
Product
Figures
Specificity
Applications
Price
Human
ELISA, Flow Cytometry, Functional Assay, Kinetics
$486
Cat # M05615-1
100 μg
Cat # M05615-1
100 μg
ENPP3 Overview
Facts about Ectonucleotide pyrophosphatase/phosphodiesterase family member 3.
Ectonucleotide pyrophosphatase/phosphodiesterase family member 3 (ENPP3)
Hydrolase that metabolizes extracellular nucleotides, such as ATP, GTP, UTP and CTP (PubMed:29717535). Limits mast cell and basophil responses during inflammation and during the chronic phases of allergic reactions by eliminating the extracellular ATP that acts as signaling molecule and triggers basophils and mast cells and induces the release of inflammatory cytokines.
Metabolizes extracellular ATP in the lumen of the small intestine, and thereby prevents ATP-induced apoptosis of intestinal plasmacytoid dendritic cells (By similarity). Has also alkaline phosphodiesterase activity (PubMed:11342463).
Gene Information
| Human | |
|---|---|
| Gene Name: | ENPP3 |
| Uniprot: | O14638 |
| Entrez: | 5169 |
Family
| Belongs to: |
|---|
| nucleotide pyrophosphatase/phosphodiesterase family |
Alternative Names
B10; CD203c antigen; CD203c; dJ1005H11.3 (phosphodiesterase I/nucleotide pyrophosphatase 3); dJ914N13.3 (phosphodiesterase I/nucleotide pyrophosphatase 3); ectonucleotide pyrophosphatase/phosphodiesterase 3; ectonucleotide pyrophosphatase/phosphodiesterase family member 3; E-NPP 3; ENPP3; ENPP-3; gp130RB13-6; NPP3; PD-IBETA; PDNP3; PDNP3B10; Phosphodiesterase I beta; Phosphodiesterase I/nucleotide pyrophosphatase 3; phosphodiesterase-I beta
Molecular Weight
Mass (kDA):
100.124 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 6q23.2 |
| Sequence: | 6; NC_000006.12 (131637302..131747413) |
Tissue Specificity
Detected on bile ducts in liver, and in blood serum (at protein level) (PubMed:15072822). Detected in prostate and uterus (PubMed:9344668). Detected on basophils, but not neutrophils (PubMed:11342463).
Subcellular Localizations
Cell membrane; Single-pass type II membrane protein. Apical cell membrane; Single-pass type II membrane protein. Secreted. Detected at the cell surface of basophils (PubMed:11342463). Detected at the apical plasma membrane of bile duct cells (PubMed:15072822). Located to the apical surface in intestinal and kidney epithelial cells. Secreted in serum, and in lumen of epithelial cells.
Diseases
- Allergy
- Anaphylaxis
- Hay Fever
- Food Allergy
- Urticaria
- Immediate Hypersensitivity
- Asthma
- Neoplasms
- Inflammation
- Urticaria Chronic
- Mastocytosis
Pathways
- Basophil Activation
- Sensitization
- Anaphylaxis
- Localization
- Hypersensitivity
- Cell Activation
- Secretion
- Basophil Degranulation
- Histamine Secretion
- Cytokine Production
- Transport
- Intracellular Transport
- Immune Response
PTMs
- Glycosylation
Research Areas
- Protein Phosphatase
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/ENPP3
bosterbio.com/bosterbio-gene-info-cards/ENPP3
References
PMID: 9344668 by Piao J.-H., et al. Molecular cloning and chromosomal localization of PD-Ibeta (PDNP3), a new member of the human phosphodiesterase I genes.
PMID: 11342463 by Buehring H.J., et al. The basophil activation marker defined by antibody 97A6 is identical to the ectonucleotide pyrophosphatase/phosphodiesterase 3.
1 Publications of Boster ENPP3 Antibodies & ELISA Kits
- PubMed ID: 10.1002/pmic.201700443, Impacts of Dietary Pleurotus eryngii Polysaccharide on Nutrient Digestion, Metab...
*More publications can be found for each product on its corresponding product page