Ephrin type-B receptor 3 (EPHB3)

Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is known as forward signaling while the signaling pathway downstream of the ephrin ligand is known as reverse signaling.

Like EPHB2, functions in axon guidance during development regulating for instance the neurons forming the corpus callosum and the anterior commissure, 2 important interhemispheric connections between the temporal lobes of the cerebral cortex. In addition to its role in axon guidance plays an important redundant role with other ephrin-B receptors in development and maturation of dendritic spines as well as the formation of excitatory synapses.