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- Table of Contents
Ephrin type-B receptor 4 Antibodies
AND EPHB4 ELISA kits, Ephrin type-B receptor 4 Proteins
Many biological assays use antibodies to detect Ephrin type-B receptor 4, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Ephrin type-B receptor 4 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Ephrin type-B receptor 4 antibodies...
Designing a Western blot for Ephrin type-B receptor 4? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the EPHB4 Western Blot GuideDesigning an IHC experiment for Ephrin type-B receptor 4? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.
Open the EPHB4 IHC GuideEPHB4 Infographic by Boster Bio
All EPHB4 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse
ELISA, Flow Cytometry, Functional Assay, Kinetics
$486
Cat # M00690-1
100 μg
Cat # M00690-1
100 μg
Human, Mouse, Rat
ELISA, Flow Cytometry, Functional Assay, Kinetics
$486
Cat # M00690
100 μg
Cat # M00690
100 μg
Human, Mouse, Rat
ELISA, Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # A00690-3
100 μl/vial
Cat # A00690-3
100 μl/vial
Anti-Ephrin type-B receptor 4 EphB4 Antibody
1 Citations
Human, Mouse
ELISA, IF, IHC, WB
$399
Cat # A00690
100μl
Cat # A00690
100μl
Human
$628
Cat # LS002050
20 µg, 100 µg
Cat # LS002050
20 µg, 100 µg
EPHB4 Overview
Facts about Ephrin type-B receptor 4.
Ephrin type-B receptor 4 (EPHB4)
Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling.
Together with its cognate ligand/functional ligand EFNB2 plays a central role in heart morphogenesis and angiogenesis through regulation of cell adhesion and cell migration. EPHB4- mediated forward signaling controls cellular repulsion and segregation form EFNB2-expressing cells.
Gene Information
| Human | |
|---|---|
| Gene Name: | EPHB4 |
| Uniprot: | P54760 |
| Entrez: | 2050 |
Family
| Belongs to: |
|---|
| protein kinase superfamily |
Alternative Names
EC 2.7.10; EC 2.7.10.1; EPH receptor B4; EphB4; ephrin type-B receptor 4; hepatoma transmembrane kinase; Htk; HTKephrin receptor EphB4; Mdk2; Myk1; soluble EPHB4 variant 1; soluble EPHB4 variant 2; soluble EPHB4 variant 3; Tyro11; Tyrosine-protein kinase receptor HTK; Tyrosine-protein kinase TYRO11
Molecular Weight
Mass (kDA):
108.27 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 7q22.1 |
| Sequence: | 7; NC_000007.14 (100802565..100827523, complement) |
Tissue Specificity
Abundantly expressed in placenta but also detected in kidney, liver, lung, pancreas, skeletal muscle and heart. Expressed in primitive and myeloid, but not lymphoid, hematopoietic cells. Also observed in cell lines derived from liver, breast, colon, lung, melanocyte and cervix.
Subcellular Localizations
Cell membrane; Single-pass type I membrane protein.
Diseases
- Neoplasms
- Malignant Neoplasms
- Tumor Angiogenesis
- Pathologic Neovascularization
- Carcinoma
- Neoplasm Metastasis
- Cell Invasion
- Cell Transformation, Neoplastic
- Tissue Adhesions
- Malignant Paraganglionic Neoplasm
- Malignant Neoplasm Of Breast
- Mammary Neoplasms
Interacting Proteins
- EFNB2
- EPO
Pathways
- Angiogenesis
- Cell Migration
- Cell Proliferation
- Bone Resorption
- Cell Adhesion
- Pathogenesis
- Tube Formation
- Bone Remodeling
- Localization
- Methylation
- Osteoblast Differentiation
- Cell Growth
- Vasculogenesis
PTMs
- Phosphorylation
- Methylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/EPHB4
bosterbio.com/bosterbio-gene-info-cards/EPHB4
References
PMID: 8188704 by Bennett B.D., et al. Cloning and characterization of HTK, a novel transmembrane tyrosine kinase of the EPH subfamily.
PMID: 11239002 by Wilson M.D., et al. Comparative analysis of the gene-dense ACHE/TFR2 region on human chromosome 7q22 with the orthologous region on mouse chromosome 5.
1 Publications of Boster Ephrin type-B receptor 4 Antibodies & ELISA Kits
- PubMed ID: 10.1186/s12860-020-00273-2, EphB4/ TNFR2/ERK/MAPK signaling pathway comprises a signaling axis to mediate th...
*More publications can be found for each product on its corresponding product page