Histone-lysine N-methyltransferase EZH1 (EZH1)

Polycomb group (PcG) protein. Catalytic subunit of the PRC2/EED-EZH1 complex, which methylates'Lys-27' of histone H3, resulting in transcriptional repression of the affected target gene.

Able to mono-, di- and trimethylate'Lys-27' of histone H3 to form H3K27me1, H3K27me2 and H3K27me3, respectively. Required for embryonic stem cell derivation and self-renewal, suggesting that it is involved with protecting embryonic stem cell identity.