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- Table of Contents
EZH1 Antibodies
AND EZH1 ELISA kits, EZH1 Proteins
Many biological assays use antibodies to detect EZH1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with EZH1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop EZH1 antibodies...
Designing a Western blot for EZH1? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the EZH1 Western Blot GuideDesigning an IHC experiment for EZH1? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.
Open the EZH1 IHC GuideEZH1 Infographic by Boster Bio
All EZH1 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
ELISA, Flow Cytometry, IF, ICC, WB
$370
Cat # A02494-1
100 µg/vial
Cat # A02494-1
100 µg/vial
EZH1 Overview
Facts about Histone-lysine N-methyltransferase EZH1.
Histone-lysine N-methyltransferase EZH1 (EZH1)
Polycomb group (PcG) protein. Catalytic subunit of the PRC2/EED-EZH1 complex, which methylates'Lys-27' of histone H3, resulting in transcriptional repression of the affected target gene.
Able to mono-, di- and trimethylate'Lys-27' of histone H3 to form H3K27me1, H3K27me2 and H3K27me3, respectively. Required for embryonic stem cell derivation and self-renewal, suggesting that it is involved with protecting embryonic stem cell identity.
Gene Information
| Human | |
|---|---|
| Gene Name: | EZH1 |
| Uniprot: | Q92800 |
| Entrez: | 2145 |
Family
| Belongs to: |
|---|
| class V-like SAM-binding methyltransferase superfamily |
Alternative Names
EC 2.1.1.43; enhancer of zeste homolog 1 (Drosophila); Enhancer of zeste homolog 1; ENX-2; histone-lysine N-methyltransferase EZH1; KIAA0388enhancer of zeste (Drosophila) homolog 1; KMT6B
Molecular Weight
Mass (kDA):
85.271 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 17q21.2 |
| Sequence: | 17; NC_000017.11 (42700275..42745078, complement) |
Subcellular Localizations
Nucleus. Colocalizes with trimethylated 'Lys-27' of histone H3.
Diseases
- Malignant Neoplasms
- Neoplasms
- Cell Transformation, Neoplastic
- Myeloid Leukemia
- Leukemia, Myelocytic, Acute
- Leukemia
- Malignant Neoplasm Of Breast
- Lymphoma
- Malignant Paraganglionic Neoplasm
- Myeloproliferative Disease
- Neoplasm Metastasis
- Mutation Abnormality
- Inflammatory Bowel Diseases
Pathways
- Cell Cycle
- Gene Silencing
- Methylation
- Cell Differentiation
- Pathogenesis
- Chromatin Remodeling
- Transport
- Muscle Cell Differentiation
- Cell Killing
- Stem Cell Differentiation
- Aging
- Stem Cell Maintenance
- Ectoderm Development
PTMs
- Methylation
Research Areas
- Chromatin Research
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/EZH1
bosterbio.com/bosterbio-gene-info-cards/EZH1
References
PMID: 8921387 by Abel K.J., et al. Characterization of EZH1, a human homolog of Drosophila Enhancer of zeste near BRCA1.
PMID: 9473645 by Ogawa M., et al. Cloning and expression of a human/mouse Polycomb group gene, ENX- 2/Enx-2.
1 Publications of Boster EZH1 Antibodies & ELISA Kits
- PubMed ID: 26265454, Enhancer of zeste homolog 2 silencing inhibits tumor growth and lung metastasis ...
*More publications can be found for each product on its corresponding product page