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Able to mono-, di- and trimethylate'Lys-27' of histone H3 to form H3K27me1, H3K27me2 and H3K27me3, respectively. Required for embryonic stem cell derivation and self-renewal, suggesting that it is involved with protecting embryonic stem cell identity.
|class V-like SAM-binding methyltransferase superfamily|
|Sequence:||17; NC_000017.11 (42700275..42745078, complement)|
Nucleus. Colocalizes with trimethylated 'Lys-27' of histone H3.